Syringe packaging system including oxygen absorber

ABSTRACT

A syringe packaging system that includes a packaging member defining a first compartment, a second compartment, and a third compartment that are in gaseous communication theretogether is disclosed. The first compartment is structured to receive a syringe barrel therein, the second compartment is structured to receive a plunger rod therein, and the third compartment is structured to receive an oxygen absorber therein. With the packaging member enclosing the syringe barrel, the plunger rod, and the oxygen absorber, the oxygen absorber is adapted to draw oxygen from within the syringe barrel and to absorb oxygen contained within at least one of the first compartment, the second compartment, and the third compartment of the packaging member. The syringe packaging system of the present disclosure also allows for reduced storage space of a syringe assembly.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to U.S. Provisional Application No.61/933,071, filed Jan. 29, 2014, the entire disclosure of which ishereby incorporated by reference.

BACKGROUND OF THE INVENTION

1. Field of the Disclosure

The present disclosure relates generally to a syringe assembly adaptedfor delivery of a fluid. More particularly, the present disclosurerelates to a syringe assembly in which the plunger rod and the syringebarrel may be placed in a packaging enclosure in a manner that allowsfor reduced levels of oxygen within the packaging enclosure and reducedlevels of oxygen contained in a fluid or drug disposed within thesyringe barrel.

2. Description of the Related Art

Syringe assemblies, and in particular hypodermic syringes, are wellknown in the medical field for dispensing fluids, such as medications. Aconventional syringe typically includes a syringe barrel with an openingat one end and a plunger mechanism disposed through the opposite end.The plunger mechanism typically includes a plunger rod extending throughthe barrel, with a plunger head or stopper disposed at the end of theplunger rod within the syringe barrel, and with a finger flange at theother end of the plunger rod extending out of the syringe barrel. Inuse, the plunger rod is retracted through the syringe barrel to aspirateor fill the syringe barrel with a fluid, such as a medication, with theplunger rod extending out from the rear end of the syringe barrel. Fordelivery of the medication to a patient, the opening of the syringebarrel is adapted for fluid communication with a patient, such asthrough a hypodermic needle fitted at the front end of the syringebarrel or through a luer-type fitting extending from the syringe barrelfor attachment with a fluid line of a patient. Upon application of aforce to depress the plunger rod and stopper through the syringe barreltowards the front end of the syringe barrel, the contents of the syringeare thereby forced out of the syringe barrel through the opening at thefront end for delivery to the patient.

Commonly, hypodermic syringes may be packaged as “pre-filled” devices,wherein the syringe is pre-filled with medication prior to beingpackaged and delivered to the patient. In this manner, the need for theuser to fill the device prior to injection is eliminated, thereby savingtime and maintaining consistent volumes for delivery. However, packagingof such pre-filled syringes may include atmospheric gases such as oxygenwithin the packaging which can cause a medication or drug containedwithin the syringe barrel to degrade and which can reduce the shelf lifeof the pre-filled syringe assembly. Accordingly, there is a need for asyringe packaging that reduces oxygen levels therein.

SUMMARY OF THE INVENTION

In accordance with an embodiment of the present invention, a syringepackaging system includes a syringe barrel, a plunger rod, an oxygenabsorber, and a packaging member. The packaging member defines a firstcompartment, a second compartment, and a third compartment, the firstcompartment, the second compartment, and the third compartment ingaseous communication. The first compartment is structured to receivethe syringe barrel therein, the second compartment is structured toreceive the plunger rod therein, and the third compartment is structuredto receive the oxygen absorber therein. With the packaging memberenclosing the syringe barrel, the plunger rod, and the oxygen absorber,the oxygen absorber is adapted to draw oxygen from within the syringebarrel and to absorb oxygen contained within at least one of the firstcompartment, the second compartment, and the third compartment of thepackaging member.

In certain configurations, the syringe barrel includes a first end, asecond end, and a sidewall extending therebetween and defining a chamberhaving an interior, the syringe barrel also includes a stopper slidablydisposed within the interior of the chamber. The plunger rod may beengageable with a portion of the stopper. In certain configurations, thesyringe packaging system includes a fluid disposed within the chamber ofthe syringe barrel.

With the packaging member enclosing the syringe barrel, the plunger rod,and the oxygen absorber, the oxygen absorber is adapted to draw oxygenfrom the fluid disposed within the chamber of the syringe barrel. In oneconfiguration, the oxygen absorber is adapted to draw oxygen from thefluid disposed within the chamber through the stopper. In anotherconfiguration, the oxygen absorber is adapted to draw oxygen from thefluid disposed within the chamber through the syringe barrel.

The packaging member may also include a sealing member such that thepackaging member and the sealing member enclose the syringe barrel, theplunger rod, and the oxygen absorber. The first compartment, the secondcompartment, and the third compartment may be formed as portions of aunitary compartment. In certain configurations, the syringe packagingsystem also includes a partition member receivable within the packagingmember, the partition member and the packaging member defining the firstcompartment, the second compartment, and the third compartment. Thepartition member may define a plurality of gas holes allowing forgaseous communication between at least two of the first compartment, thesecond compartment, and the third compartment.

The packaging member may also include a sidewall defining opposing slotsfor receiving the partition member. The packaging member may optionallyinclude at least one rib for engaging the oxygen absorber to secure theoxygen absorber within the packaging member. The packaging member mayalso include a support member for engaging the plunger rod to secure theplunger rod within the packaging member. Optionally, the packagingmember may include a support member for engaging the syringe barrel tosecure the syringe barrel within the packaging member.

In still other configurations, the packaging member may include atapered portion of a sidewall for securing the oxygen absorber withinthe packaging member. The packaging member may also include a firstprotrusion and a second protrusion and the partition member may be atleast partially receivable between the first protrusion and the secondprotrusion. The packaging member may also include a fin for engaging theoxygen absorber to secure the oxygen absorber within the packagingmember. Optionally, the packaging member includes an internal wall forsecuring the oxygen absorber within the packaging member, and a lidhaving an aperture, with the lid securable to the internal wall. Theoxygen absorber may include a polyolefin based material.

In accordance with another embodiment of the present invention, asyringe packaging system includes a syringe barrel having a first end, asecond end, and a sidewall extending therebetween and defining a chamberhaving an interior. The syringe packaging system also includes a stopperslidably disposed within the interior of the chamber of the syringebarrel, and a fluid disposed within the chamber of the syringe barrel,wherein at least one of the syringe barrel and the stopper are formed ofan oxygen permeable material. The syringe packaging system also includesa plunger rod engageable with a portion of the stopper and an oxygenabsorber. The syringe packaging system further includes a packagingmember formed of a generally oxygen impermeable material and defining afirst compartment, a second compartment, and a third compartment, thefirst compartment, the second compartment, and the third compartment ingaseous communication. The first compartment is structured to receivethe syringe barrel therein, the second compartment is structured toreceive the plunger rod therein, and the third compartment is structuredto receive the oxygen absorber therein. With the packaging memberenclosing the syringe barrel, the plunger rod, and the oxygen absorber,the oxygen absorber is adapted to draw oxygen from the fluid disposedwithin the chamber of the syringe barrel and to absorb oxygen containedwithin the packaging member.

In certain configurations, the oxygen absorber is adapted to draw oxygenfrom the fluid disposed within the chamber through the stopper. In otherconfigurations, the oxygen absorber is adapted to draw oxygen from thefluid disposed within the chamber through the syringe barrel.

The packaging member may include a sealing member, and the packagingmember and the sealing member may enclose the syringe barrel, theplunger rod, and the oxygen absorber. The first compartment, the secondcompartment, and the third compartment may be formed as portions of aunitary compartment. Optionally, the packaging member may be formed of apolyester material or a polyamide material.

In accordance with yet another embodiment of the present invention, asyringe packaging system includes a syringe barrel, an oxygen absorber,and a packaging member defining a first compartment and a secondcompartment, with the first compartment and the second compartment ingaseous communication. The first compartment is structured to receivethe syringe barrel therein and the second compartment is structured toreceive the oxygen absorber therein. With the packaging member enclosingthe syringe barrel and the oxygen absorber, the oxygen absorber isadapted to draw oxygen from within the syringe barrel.

In certain configurations, the syringe barrel includes a first end, asecond end, and a sidewall extending therebetween and defining a chamberhaving an interior, the syringe barrel further includes a stopperslidably disposed within the interior of the chamber. In certainconfigurations, the syringe packaging system also includes a fluiddisposed within the chamber of the syringe barrel. With the packagingmember enclosing the syringe barrel and the oxygen absorber, the oxygenabsorber may be adapted to draw oxygen from the fluid disposed withinthe chamber of the syringe barrel. The oxygen absorber may be adapted todraw oxygen from the fluid disposed within the chamber through thestopper. In other configurations, the oxygen absorber may be adapted todraw oxygen from the fluid disposed within the chamber through thesyringe barrel.

BRIEF DESCRIPTION OF THE DRAWINGS

The above-mentioned and other features and advantages of thisdisclosure, and the manner of attaining them, will become more apparentand the disclosure itself will be better understood by reference to thefollowing descriptions of embodiments of the disclosure taken inconjunction with the accompanying drawings, wherein:

FIG. 1 is an exploded, perspective view of a syringe packaging system inaccordance with an embodiment of the present invention.

FIG. 2A is an assembled, perspective view of the syringe packagingsystem of FIG. 1 in accordance with an embodiment of the presentinvention.

FIG. 2B is an assembled, perspective view of the syringe packagingsystem of FIG. 1, with a sealing member sealing the syringe packagingsystem in accordance with an embodiment of the present invention.

FIG. 3A is a cross-sectional view of the syringe packaging system ofFIG. 2A in accordance with an embodiment of the present invention.

FIG. 3B is a cross-sectional view of the syringe packaging system ofFIG. 2A with a fluid disposed within a chamber of a syringe barrel inaccordance with an embodiment of the present invention.

FIG. 4 is a perspective view of a packaging member in accordance with anembodiment of the present invention.

FIG. 5 is a top view of a packaging member in accordance with anembodiment of the present invention.

FIG. 6 is a side elevation view of a packaging member in accordance withan embodiment of the present invention.

FIG. 7 is a cross-sectional view of a packaging member taken along line7-7 of FIG. 6 in accordance with an embodiment of the present invention.

FIG. 8 is another side elevation view of a packaging member inaccordance with an embodiment of the present invention.

FIG. 9 is a cross-sectional view of a packaging member taken along line9-9 of FIG. 8 in accordance with an embodiment of the present invention.

FIG. 10 is a perspective view of a partition member in accordance withan embodiment of the present invention.

FIG. 11 is a side elevation view of a partition member in accordancewith an embodiment of the present invention.

FIG. 12 is a top view of a partition member in accordance with anembodiment of the present invention.

FIG. 13 is another side elevation view of a partition member inaccordance with an embodiment of the present invention.

FIG. 14 is a bottom view of a partition member in accordance with anembodiment of the present invention.

FIG. 15 is an exploded, perspective view of a syringe barrel and aplunger rod in accordance with an embodiment of the present invention.

FIG. 16 is a perspective view of an oxygen absorber in accordance withan embodiment of the present invention.

FIG. 17 is an exploded, perspective view of a syringe barrel, a stopperadapter, and a plunger rod in accordance with an embodiment of thepresent invention.

FIG. 18A is a fragmentary, cross-sectional view of the plunger rod andthe stopper adapter in an engaged position in accordance with anembodiment of the present invention.

FIG. 18B is a fragmentary, cross-sectional view of the plunger rod andthe stopper adapter in an engaged position and the stopper adapter and astopper in an engaged position in accordance with an embodiment of thepresent invention.

FIG. 19 is an exploded view of a syringe barrel, a stopper, a stopperadapter, and a plunger rod in accordance with an embodiment of thepresent invention.

FIG. 20 is an exploded cross-sectional view of the syringe barrel, thestopper, the stopper adapter, and the plunger rod of FIG. 19 taken alongline 20-20 in accordance with an embodiment of the present invention.

FIG. 21 is an assembled, perspective view of the syringe barrel, thestopper, and the plunger rod of FIG. 17 in accordance with an embodimentof the present invention.

FIG. 22 is a top view of a syringe assembly in accordance with anembodiment of the present invention.

FIG. 23 is a cross-sectional view of a syringe assembly taken along line23-23 of FIG. 22 in accordance with an embodiment of the presentinvention.

FIG. 24 is a perspective view of a packaging member in accordance withan embodiment of the present invention.

FIG. 25 is a side elevation view of a packaging member in accordancewith an embodiment of the present invention.

FIG. 26 is a cross-sectional view of a packaging member taken along line26-26 of FIG. 25 in accordance with an embodiment of the presentinvention.

FIG. 27 is another side elevation view of a packaging member inaccordance with an embodiment of the present invention.

FIG. 28 is a cross-sectional view of a packaging member taken along line28-28 of FIG. 27 in accordance with an embodiment of the presentinvention.

FIG. 29 is a top view of a packaging member in accordance with anembodiment of the present invention.

FIG. 30 is a perspective view of a partition member and an oxygenabsorber in accordance with an embodiment of the present invention.

FIG. 31 is a schematic cross-sectional view of a syringe packagingsystem in accordance with an embodiment of the present invention.

FIG. 32 is an enlarged partial view of the syringe packaging system ofFIG. 31 in accordance with an embodiment of the present invention.

FIG. 33 is an enlarged partial cross-sectional view of the syringepackaging system of FIG. 31 with a partition member received between afirst bump and a second bump in accordance with an embodiment of thepresent invention.

FIG. 34 is a perspective view of a packaging member in accordance withan embodiment of the present invention.

FIG. 35 is a side elevation view of a packaging member in accordancewith an embodiment of the present invention.

FIG. 36 is a cross-sectional view of a packaging member taken along line36-36 of FIG. 35 in accordance with an embodiment of the presentinvention.

FIG. 37 is another side elevation view of a packaging member inaccordance with an embodiment of the present invention.

FIG. 38 is a cross-sectional view of a packaging member taken along line38-38 of FIG. 37 in accordance with an embodiment of the presentinvention.

FIG. 39 is an exploded, perspective view of a syringe packaging systemin accordance with an embodiment of the present invention.

FIG. 40 is a side elevation view of a lid and an oxygen absorber inaccordance with an embodiment of the present invention.

FIG. 41 is a perspective view of a lid and an oxygen absorber inaccordance with an embodiment of the present invention.

FIG. 42 is a top view of a packaging member in accordance with anembodiment of the present invention.

FIG. 43 is a side elevation view of a lid and an oxygen absorber inaccordance with an embodiment of the present invention.

FIG. 44 is a schematic cross-sectional view of a syringe packagingsystem in accordance with an embodiment of the present invention.

FIG. 45 is a perspective view of a packaging member in accordance withan embodiment of the present invention.

FIG. 46 is a top view of a packaging member in accordance with anembodiment of the present invention.

FIG. 47 is a side elevation view of a packaging member in accordancewith an embodiment of the present invention.

FIG. 48 is a cross-sectional view of a packaging member taken along line48-48 of FIG. 47 in accordance with an embodiment of the presentinvention.

FIG. 49 is another side elevation view of a packaging member inaccordance with an embodiment of the present invention.

FIG. 50 is a cross-sectional view of a packaging member taken along line50-50 of FIG. 49 in accordance with an embodiment of the presentinvention.

FIG. 51 is an exploded, perspective view of a syringe packaging systemin accordance with an embodiment of the present invention.

FIG. 52 is an assembled, perspective view of the syringe packagingsystem of FIG. 51 in accordance with an embodiment of the presentinvention.

FIG. 53 is a cross-sectional view of the syringe packaging system ofFIG. 52 in accordance with an embodiment of the present invention.

FIG. 54 is a perspective view of a packaging member in accordance withan embodiment of the present invention.

FIG. 55 is a top view of a packaging member in accordance with anembodiment of the present invention.

FIG. 56 is a side elevation view of a packaging member in accordancewith an embodiment of the present invention.

FIG. 57 is a cross-sectional view of a packaging member taken along line57-57 of FIG. 56 in accordance with an embodiment of the presentinvention.

FIG. 58 is another side elevation view of a packaging member inaccordance with an embodiment of the present invention.

FIG. 59 is a cross-sectional view of a packaging member taken along line59-59 of FIG. 58 in accordance with an embodiment of the presentinvention.

FIG. 60 is an exploded, perspective view of a syringe packaging systemin accordance with an embodiment of the present invention.

FIG. 61 is an assembled, top view of the syringe packaging system ofFIG. 60 in accordance with an embodiment of the present invention.

FIG. 62 is a perspective view of a packaging member in accordance withan embodiment of the present invention.

FIG. 63 is a top view of a packaging member in accordance with anembodiment of the present invention.

FIG. 64 is a side elevation view of a packaging member in accordancewith an embodiment of the present invention.

FIG. 65 is a cross-sectional view of a packaging member taken along line65-65 of FIG. 64 in accordance with an embodiment of the presentinvention.

FIG. 66 is another side elevation view of a packaging member inaccordance with an embodiment of the present invention.

FIG. 67 is a cross-sectional view of a packaging member taken along line67-67 of FIG. 66 in accordance with an embodiment of the presentinvention.

FIG. 68 is an exploded, perspective view of a syringe packaging systemin accordance with an embodiment of the present invention.

FIG. 69 is an assembled, perspective view of the syringe packagingsystem of FIG. 68 in accordance with an embodiment of the presentinvention.

FIG. 70 is a cross-sectional view of the syringe packaging system ofFIG. 69 in accordance with an embodiment of the present invention.

Corresponding reference characters indicate corresponding partsthroughout the several views. The exemplifications set out hereinillustrate exemplary embodiments of the disclosure, and suchexemplifications are not to be construed as limiting the scope of thedisclosure in any manner.

DETAILED DESCRIPTION

For purposes of the description hereinafter, the terms “upper”, “lower”,“right”, “left”, “vertical”, “horizontal”, “top”, “bottom”, “lateral”,“longitudinal”, and derivatives thereof shall relate to the invention asit is oriented in the drawing figures. However, it is to be understoodthat the invention may assume various alternative variations, exceptwhere expressly specified to the contrary. It is also to be understoodthat the specific devices illustrated in the attached drawings, anddescribed in the following specification, are simply exemplaryembodiments of the invention. Hence, specific dimensions and otherphysical characteristics related to the embodiments disclosed herein arenot to be considered as limiting.

In the following discussion, “distal” refers to a direction generallytoward an end of a syringe assembly adapted for contact with a patientand/or engagement with a separate device such as a needle assembly or IVconnection assembly, and “proximal” refers to the opposite direction ofdistal, i.e., away from the end of a syringe assembly adapted forengagement with the separate device. For purposes of this disclosure,the above-mentioned references are used in the description of thecomponents of a syringe assembly in accordance with the presentdisclosure.

FIGS. 1-23 illustrate an exemplary embodiment of the present disclosure.Referring to FIGS. 1-9 and 15-23, a syringe packaging system 10 includesa packaging member 12, a syringe assembly 13 including a syringe barrel14 and a detachable plunger rod 16, and an oxygen absorber 18. With thepackaging member 12 enclosing the syringe barrel 14, the plunger rod 16,and the oxygen absorber 18, the oxygen absorber 18 is adapted to drawoxygen from the syringe barrel 14 and to absorb oxygen contained withinthe packaging member 12. The syringe packaging system 10 of the presentdisclosure also allows for reduced storage space of a syringe assembly.

Referring to FIGS. 1-3B, the packaging member 12 is sized and adapted toreceive syringe barrel 14, plunger rod 16, and oxygen absorber 18therein. Referring to FIGS. 15 and 17-23, in one embodiment, syringeassembly 13 includes syringe barrel 14, plunger rod 16, and a stopperassembly including a stopper 19 and a stopper adapter 21. Syringeassembly 13 may be adapted for dispensing and delivery of a fluid and/orcollection of a fluid. For example, syringe assembly 13 may be used forinjection or infusion of fluid such as a medication or drug into apatient. Syringe assembly 13 is contemplated for use in connection witha needle, such as by connecting syringe assembly 13 to a separate needleassembly (not shown), or alternatively for connection with anintravenous (IV) connection assembly (not shown). It can be appreciatedthat the present disclosure can be used with any type of syringeassembly, particularly those which are placed in a controlled storageenvironment in which storage space is limited. These types of syringesinclude traditional pre-filled syringe assemblies, metered dosesyringes, aspiration syringes for withdrawing fluid from a patient ormedication from a container, and the like.

Referring to FIGS. 15 and 17-23, syringe barrel 14 generally includes abarrel body having a sidewall 30 extending between a first or distal end32 and a second or proximal end 34. Sidewall 30 defines an elongateaperture or interior chamber 36 of syringe barrel 14. In one embodiment,interior chamber 36 may span the extent of syringe barrel 14 so thatsyringe barrel 14 is cannulated along its entire length. In oneembodiment, syringe barrel 14 may be in the general form of an elongatedcylindrical barrel as is known in the art in the general shape of ahypodermic syringe. In alternative embodiments, syringe barrel 14 may bein other forms for containing a fluid for delivery, such as in thegeneral form of an elongated rectangular barrel, for example. Syringebarrel 14 may be formed of glass, or may be injection molded fromthermoplastic material such as polypropylene and polyethylene accordingto techniques known to those of ordinary skill in the art, though it isto be appreciated that syringe barrel 14 may be made from other suitablematerials and according to other applicable techniques. In certainconfigurations, syringe barrel 14 may include an outwardly extendingflange 40 about at least a portion of proximal end 34. Flange 40 may beconfigured for easy grasping by a medical practitioner, as will bediscussed herein.

Distal end 32 of syringe barrel 14 includes an outlet opening 38 (FIGS.3A and 3B) which is in fluid communication with chamber 36. Outletopening 38 may be sized and adapted for engagement with a separatedevice, such as a needle assembly or IV connection assembly and,therefore, may include a mechanism for such engagement as isconventionally known. For example, distal end 32 may include agenerally-tapered luer tip for engagement with an optional separatetapered luer structure of such a separate device for attachmenttherewith (not shown). In one configuration, both the tapered luer tipand the separate tapered luer structure may be provided with the syringeassembly 13. In such a configuration, the separate tapered luerstructure may be fitted with an attachment mechanism, such as a threadedengagement, for corresponding engagement with a separate device (notshown). In another configuration, the tapered luer tip may be providedfor direct engagement with a separate device (not shown). In addition, amechanism for locking engagement therebetween may also be provided withat least one of the tapered luer tip and/or the separate tapered luerstructure, such as a luer collar or luer lock including interiorthreads. Such luer connections and luer locking mechanisms are wellknown in the art.

Proximal end 34 of syringe barrel 14 is generally open-ended, but isintended to be closed off to the external environment as discussedherein. Syringe barrel 14 may also include markings, such as graduationslocated on sidewall 30, for providing an indication as to the level oramount of fluid contained within interior chamber 36 of syringe barrel14. Such markings may be provided on an external surface of sidewall 30,an internal surface of sidewall 30, or integrally formed or otherwisewithin sidewall 30 of syringe barrel 14. In other embodiments,alternatively, or in addition thereto, the markings may also provide adescription of the contents of the syringe or other identifyinginformation as may be known in the art, such as maximum and/or minimumfill lines.

Syringe barrel 14 may be useful as a pre-filled syringe, and, therefore,may be provided for end use with a fluid F (FIG. 3B), such as amedication or drug, contained within interior chamber 36 of syringebarrel 14, pre-filled by the manufacturer. In this manner, syringebarrel 14 can be manufactured, pre-filled with a medication, sterilized,and packaged in appropriate packaging such as packaging member 12 fordelivery, storage, and use by the end user, without the need for the enduser to fill the syringe with medication from a separate vial prior touse. In such an embodiment, syringe barrel 14 may include a tip cap orsealing cap member 42 including a seal 44 disposed at distal end 32 ofsyringe barrel 14 to seal a fluid F, such as a medication, withininterior chamber 36 of syringe barrel 14.

As used herein, the term “drug” refers to a pharmaceutically activeingredient(s) and any pharmaceutical liquid composition containing thepharmaceutically active ingredient(s). Pharmaceutical liquidcompositions include forms such as solutions, suspensions, emulsions,and the like. These pharmaceutical liquid compositions can beadministered orally or by injection.

Any drug that is oxygen sensitive, i.e., can degrade as a result ofexposure to oxygen, is suitable for incorporation into thepharmaceutical packaging systems described herein. Oxygen sensitivedrugs include those that have amines either as salts or free bases,sulfides, allylic alcohols, phenols and other chemical groups that canhave reactivity with oxygen. Non-limiting examples of oxygen sensitivedrugs include morphine, hydromorphone, promethazine, dopamine,epinephrine, norepinephrine, esterified estrogen, ephedrine,pseudoephedrine, acetaminophen, ibuprofen, danofloxacin, erythromycin,penicillin, cyclosporine, methyldopate, cetirizine, diltiazem,verapamil, mexiletine, chlorothiazide, carbamazepine, selegiline,oxybutynin, vitamin A, vitamin B, vitamin C, L-cysteine, L-trytophan,and the like. In some embodiments, the packaging container, e.g.,syringe barrel 14, of the pharmaceutical packaging systems describedherein contain morphine. In other embodiments, the packaging containerof the pharmaceutical packaging systems described herein containhydromorphone. In further embodiments, the packaging container of thepharmaceutical packaging systems described herein contain promethazine.

The oxygen sensitive drugs in the pharmaceutical packaging systemsdescribed herein are stable in various storage conditions includingambient, intermediate, and accelerated conditions. Stability as usedherein refers to a formulation meeting all stability criteria along itsparticular shelf life, as defined in the USP or equivalent monograph ofthe drug product (for the assay of the drug substance in particular) andthe current stability criteria of the ICH Q3B guidance for impurities.All critical quality attributes need to stay in their acceptance rangethroughout the formulation's shelf life. As an example, for a morphineformulation to be stable, assay of the drug substance, i.e., morphine,is in the [90.0%-110.0%] range as per USP and per ICH Q3B guidelines,all known, i.e., identified, degradation products, such aspseudomorphine, hydroxymorphine, norphine-N-oxide, and the like, as wellas unknown degradation products need to be no more than (NMT) 0.2%.Stability of the oxygen sensitive drugs in the pharmaceutical packagingsystems described herein is assessed by HPLC, UPLC, or any other knownanalytical method.

In some embodiments an oxygen sensitive drug, when stored in thepharmaceutical packaging systems described herein, is stable in ambientconditions (e.g., 25° C./60% RH) for at least 12 months, at least 15months, at least 18 months, or at least 24 months. In certain instances,an oxygen sensitive drug, when stored in the pharmaceutical packagingsystems described herein, is stable in ambient conditions for at least24 months. In other embodiments an oxygen sensitive drug, when stored inthe pharmaceutical packaging systems described herein, is stable inintermediate conditions (e.g., 30° C./65% RH) for at least 6 months, atleast 8 months, at least 10 months, or at least 12 months. In certaininstances, an oxygen sensitive drug, when stored in the pharmaceuticalpackaging systems described herein, is stable in intermediate conditionsfor at least 12 months. In further embodiments, an oxygen sensitivedrug, when stored in the pharmaceutical packaging systems describedherein, is stable in accelerated conditions (e.g., 40° C./75% RH) for atleast 4 months, at least 5 months, or at least 6 months. In certaininstances, an oxygen sensitive drug, when stored in the pharmaceuticalpackaging systems described herein, is stable in accelerated conditionsfor at least 6 months.

The pharmaceutical packaging systems described herein are also suitablefor pharmaceutical liquid compositions comprising an oxygen-sensitiveexcipient. Degradation of oxygen-sensitive excipients in apharmaceutical composition can lead to a variety of effects ranging fromdiscoloration of the composition, reduced performance or efficiency ofthe composition, and/or harmful reactivity with the activepharmaceutical ingredient. Nonexclusive examples of oxygen-sensitiveexcipients that benefit from the pharmaceutical packaging systemsdescribed herein include polyethylene oxide (PEO) or polyethylene glycol(PEG) and polyoxyethylene alkyl ethers.

In one embodiment, at least a portion of syringe barrel 14 such assidewall 30, distal end 32, and/or proximal end 34 includes an oxygenpermeable member such that oxygen may pass from chamber 36 of syringebarrel 14 to oxygen absorber 18 as will be described in more detailbelow. For example, in one embodiment, tip cap or cap member 42 may beformed of an oxygen permeable material so that oxygen may pass fromchamber 36 of syringe barrel 14 to oxygen absorber 18. In oneembodiment, cap member 42 may be formed of a cyclic olefin polymer whichis oxygen permeable and appropriate for contact with fluid F. Further,it is contemplated that cap member 42 may be formed of other materialswhich are capable of allowing oxygen to pass from chamber 36 of syringebarrel 14 to oxygen absorber 18. In other embodiments, proximal end 34or sidewall 30 of syringe barrel 14 may include and/or be formed of anoxygen permeable member so that oxygen may pass from chamber 36 ofsyringe barrel 14 to oxygen absorber 18.

Referring to FIGS. 17-23, syringe assembly 13 includes stopper 19 whichis moveably or slidably disposed within interior chamber 36 of syringebarrel 14, and in sealing contact with the internal surface of sidewall30 of syringe barrel 14. Stopper 19 is sized relative to syringe barrel14 to provide sealing engagement with the interior surface of sidewall30 of syringe barrel 14. Additionally, stopper 19 may include one ormore annular ribs extending around the periphery of stopper 19 toincrease the sealing engagement between stopper 19 and the interiorsurface of sidewall 30 of syringe barrel 14. In alternate embodiments, asingular O-ring or a plurality of O-rings may be circumferentiallydisposed about stopper 19 to increase the sealing engagement with theinterior surface of sidewall 30 of syringe barrel 14.

Referring to FIGS. 17-23, in one embodiment, stopper 19 also includes afirst or distal end 51 and a second or proximal end 53 defining astopper adapter receiving aperture 55 formed therein and having athreaded portion 57 for securing stopper adapter 21 to stopper 19.

Referring to FIGS. 17-23, in one embodiment, stopper adapter 21 includesa first or distal end 50 and a second or proximal end 52 defining aplunger receiving aperture 54 formed therein and having a securementfeature or engagement portion 56 for securing plunger rod 16 to stopper19 via stopper adapter 21. In one embodiment, referring to FIGS. 17-23,the engagement portion 56 of stopper adapter 21 may include a protrudingannular ring 58 having a tapered portion 60 and a locking end 62 as willbe described in more detail below. In one embodiment, protruding annularring 58 is formed of a rigid, unyielding material. In one embodiment,first end 50 of stopper adapter 21 includes a threaded portion 64.

In one embodiment, stopper adapter 21 can be secured to stopper 19 bythreadingly engaging threaded portion 64 of stopper adapter 21 tothreaded portion 57 of stopper 19 as shown in FIG. 18B. In otherembodiments, stopper adapter 21 can be secured to stopper 19 using aball detent, locking tabs, spring loaded locking mechanism, latch,adhesive, or other similar mechanism. In all embodiments, stopperadapter 21 is locked, secured, or engaged to stopper 19, i.e.,significant relative movement between stopper adapter 21 and stopper 19is prevented. In other alternate embodiments, stopper adapter 21 andstopper 19 may be integrally formed and both form a stopper assembly.

In other embodiments, stopper adapter 21 and stopper 19 may be co-formedsuch as by co-extrusion. In alternate embodiments, stopper adapter 21and stopper 19 may be integrally formed as a stopper assembly.

Referring to FIGS. 15 and 17-23, syringe assembly 13 further includesplunger rod 16 which provides a mechanism for dispensing fluid containedwithin interior chamber 36 of syringe barrel 14 through outlet opening38 upon connection of plunger rod 16 to syringe barrel 14 via stopperadapter 21 as will be described in more detail below. Plunger rod 16 isadapted for advancing stopper 19. In one embodiment, plunger rod 16 issized for movement within interior chamber 36 of syringe barrel 14 aswill be discussed in more detail below, and generally includes a firstor distal end 70, a second or proximal end 72, a flange 74 disposedadjacent second end 72, and a securement feature or engagement portion76 for securing plunger rod 16 to stopper 19. In one embodiment,referring to FIGS. 17-23, the engagement portion 76 of plunger rod 16may include a plunger rod head 78 having a deformable restraining membersuch as elastic fingers 80 and a neck 82 disposed adjacent plunger rodhead 78. Plunger rod head 78 also includes an annular groove 84 locatedbetween elastic fingers 80 and neck 82. Elastic fingers 80 each includea tapered portion 86 and a locking end 88. Plunger rod head 78 will bedescribed in more detail below.

In another embodiment, the engagement portion 56 of stopper adapter 21may include a deformable restraining member, e.g., elastic fingers, forsecuring plunger rod 16 to stopper 19 via stopper adapter 21. In otherembodiments, the engagement portion 56 of stopper adapter 21 may includea threaded portion, snap fit mechanism, a ball detent, locking tabs,spring loaded locking mechanism, latch, adhesive, or other similarmechanism for securing plunger rod 16 to stopper 19 via stopper adapter21.

In another embodiment, the engagement portion 76 of plunger rod 16 mayinclude a plunger rod head 78 formed of a rigid, unyielding material forsecuring plunger rod 16 to stopper 19 via stopper adapter 21. In otherembodiments, the engagement portion 76 of plunger rod 16 may include athreaded portion, snap fit mechanism, a ball detent, locking tabs,spring loaded locking mechanism, latch, adhesive, or other similarmechanism for securing plunger rod 16 to stopper 19 via stopper adapter21.

Referring to FIGS. 1-3B and 16, oxygen absorber 18 is included with thesyringe packaging system 10 of the present disclosure. By disposingoxygen absorber 18 within packaging member 12, oxygen absorber 18 canreduce the oxygen levels within packaging member 12 and remove oxygencontained in fluid F (FIG. 3B) disposed within chamber 36 of syringebarrel 14. For example, any oxygen contained within packaging member 12will be absorbed by oxygen absorber 18. Additionally, oxygen containedwithin chamber 36 of syringe barrel 14, and/or oxygen contained in fluidF disposed within chamber 36 of syringe barrel 14, will flow fromchamber 36 of syringe barrel 14 to oxygen absorber 18 via the at leastone portion of syringe barrel 14, such as sidewall 30, distal end 32,and/or proximal end 34 that includes an oxygen permeable member asdescribed above. Reduction of oxygen levels within packaging member 12is important because atmospheric gases such as oxygen contained inpackaging member 12 and contained in fluid F disposed within chamber 36of syringe barrel 14 can cause fluid F, such as a medication or drug ina pre-filled syringe, to degrade.

In one embodiment, oxygen absorber 18 may be formed of a polyolefinbased material, e.g., a polypropylene material or a polyethylenematerial, or a similar material to allow for the desired oxygenabsorption rate or kinetics. In one embodiment, oxygen absorber 18 maybe formed of iron, low molecular weight organic compounds such asascorbic acid and sodium ascorbate, and polymeric materialsincorporating a resin and a catalyst. Further, it is contemplated thatoxygen absorber 18 may be formed of other materials which are capable ofabsorbing oxygen contained within packaging member 12 and removingoxygen contained in fluid F disposed within chamber 36 of syringe barrel14. In some embodiments, suitable materials for oxygen absorbers includemetal-based substances that remove oxygen by reacting with it bychemical bonding, generally forming a metal oxide component. Exampleoxygen absorbers suitable for use in the present system are disclosed inU.S. application Ser. No. 14/207,207, the entire disclosure of which ishereby incorporated by reference herein. Metal-based substances includeelemental iron as well as iron oxide, iron hydroxide, iron carbide, andthe like. Other metals for use as oxygen absorbers include nickel, tin,copper, and zinc. Metal-based oxygen absorbers are typically in the formof a powder to increase surface area. Powder formation of themetal-based oxygen absorbers is by any known method including, but notlimited to, atomization, milling, pulverization, and electrolysis.Additional materials for oxygen absorbers include low molecular weightorganic compounds such as ascorbic acid, sodium ascorbate, catechol andphenol, activated carbon, and polymeric materials incorporating a resinand a catalyst. In some embodiments of the pharmaceutical packagingsystem, the oxygen absorber is a metal-based oxygen absorber. In certaininstances of the pharmaceutical packaging system, the oxygen absorber isan iron-based oxygen absorber. In further instances of thepharmaceutical packaging system, the oxygen absorber is an iron-basedoxygen absorber in the form of a canister.

In one embodiment, referring to FIGS. 1, 3A, 3B, and 16, oxygen absorber18 is in the form of a canister. In other embodiments, oxygen absorber18 may be in other forms such as in the form of a packet or sachet. Insome embodiments, oxygen absorber 18 may be a cylindrical shape, acapsular shape, or a similar shape to allow for the desired absorptionrate or kinetics. In this manner, the size, shape, cross-sectional area,and/or volume of oxygen absorber 18 and the position of oxygen absorber18 within packaging member 12 may be varied so that oxygen absorber 18is adapted to absorb oxygen contained within packaging member 12 and isalso adapted to remove oxygen contained in fluid F disposed withinchamber 36 of syringe barrel 14 to prevent fluid F from degrading and toincrease the shelf life of syringe packaging system 10.

The packaging systems described herein are useful for enhancingstability and preventing oxidative degradation of oxygen sensitive drugsin liquid form thereby allowing for extended product shelf life andprolonged drug potency or efficiency.

“Oxygen-sensitive” or “oxygen-sensitivity” refers to the ability of asubstance to react with oxygen under ambient temperature conditions(e.g., 5° C. to about 40° C.). The chemical reaction may involve theaddition of an oxygen atom to the substance, removal of a hydrogen fromthe substance, or the loss or removal of one or more electrons from amolecular entity, with or without concomitant loss or removal of aproton or protons.

A feature of the pharmaceutical packaging systems herein is that theconfiguration allows the absorption and removal of oxygen in all thecomponents of the system. In essence, the oxygen absorber in thepharmaceutical packaging system herein leads to the absorbance andremoval of oxygen in the secondary packaging, e.g., packaging member 12,the primary packaging, e.g., syringe barrel 14, and the drug inside theprimary packaging. The oxygen absorber further removes the low oxygeningress through the secondary packaging over time. In thisconfiguration, the residual oxygen amount that is present inside theprimary and secondary packaging due to the pharmaceutical manufacturingprocess as well as the oxygen entering the packaging system fromexternal environments over time, is reduced and even eliminated.

Another feature of the pharmaceutical packaging systems described hereinis that the pharmaceutical packaging systems maintain zero % oxygenlevel after removal of the initial oxygen in the primary packagingcontainer and secondary packaging for an extended period of time. As aresult, the pharmaceutical packaging systems described herein offerincreases in the shelf life of oxygen sensitive drugs past conventionalpackaging and methods such as from inert atmosphere packaging processes(e.g., nitrogen blanketing and/or degassing). In some embodiments, thepharmaceutical packaging systems described herein maintain zero % oxygenlevel in the primary and secondary packaging for at least about 12months, at least about 15 months, at least about 18 months, at leastabout 24 months, at least about 30 months, at least about 36 months, atleast about 48 months, or at least about 60 months. In certaininstances, the pharmaceutical packaging systems described hereinmaintain zero % oxygen level in the primary and secondary packaging forat least 12 months. In certain instances, the pharmaceutical packagingsystems described herein maintain zero % oxygen level in the primary andsecondary packaging for at least 24 months. In certain instances, thepharmaceutical packaging systems described herein maintain zero % oxygenlevel in the primary and secondary packaging for at least 36 months.

In one embodiment, the oxygen absorber in the pharmaceutical packagingsystems herein allows for the rapid uptake of oxygen present in thesecondary packaging. Oxygen in air at ambient temperature and pressure(1 atm) is at a concentration of about 21%. When a pharmaceuticalpackaging system described herein is assembled in air in ambientconditions, the environment inside the secondary packaging is initiallyalso at 21% oxygen level. The oxygen absorber in the pharmaceuticalpackaging system of the present disclosure quickly reduces the oxygenlevel in the secondary packaging to zero % in one to three days.Accordingly, in some embodiments, the oxygen absorber reduces oxygen tozero % in the secondary packaging in about seven days, in about sixdays, in about five days, in about four days, in about three days, inabout two days, or in about one day after initial packaging of theassembly. In some embodiments, the oxygen absorber reduces oxygen tozero % in the secondary packaging in about one to seven days. In someembodiments, the oxygen absorber reduces oxygen to zero % in thesecondary packaging in about one to three days. In some embodiments, theoxygen absorber reduces oxygen in the secondary packaging by about 35%,about 50%, about 60%, about 65%, about 70%, about 75%, about 80%, about85%, about 90%, or about 95% of the total oxygen in the air per dayafter initial packaging of the assembly. In certain instances, theoxygen absorber reduces oxygen in the secondary packaging by about 50%per day. In other instances, the oxygen absorber reduces oxygen in thesecondary packaging by about 75% per day. In further instances, theoxygen absorber reduces oxygen in the secondary packaging by about 90%per day. In other embodiments, the oxygen absorber reduces oxygen in thesecondary packaging by about 35% to about 75%, about 50% to about 80%,or about 65% to about 90% per day after initial packaging of theassembly.

In further embodiments, the oxygen absorber reduces about 2 to about 10cc of oxygen/day, atm; about 3 to about 8 cc of oxygen/day, atm; orabout 4 to about 6 cc of oxygen/day, atm in the secondary packaging. Incertain instances, the oxygen absorber reduces about 2, about 3, about4, about 5, about 6, about 7, about 8, about 9, or about 10 cc ofoxygen/day, atm in the secondary packaging. In some instances, theoxygen absorber reduces about 4 cc of oxygen/day, atm. In otherinstances, the oxygen absorber reduces about 6 cc of oxygen/day, atm. Infurther instances, the oxygen absorber reduces about 8 cc of oxygen/day,atm.

Another feature of the oxygen absorber is that it maintains zero %oxygen level after removal of the initial oxygen in the secondarypackaging for an extended period of time. In some embodiments, theoxygen absorber maintains zero % oxygen level in the secondary packagingfor the entire shelf life of the drug. In some embodiments, the oxygenabsorber maintains zero % oxygen level in the secondary packaging for atleast about 12 months, at least about 15 months, at least about 18months, at least about 24 months, at least about 30 months, at leastabout 36 months, at least about 48 months, or least about 60 months. Incertain instances, the oxygen absorber maintains zero % oxygen level inthe secondary packaging for at least 12 months. In certain instances,the oxygen absorber maintains zero % oxygen level in the secondarypackaging for at least 24 months. In certain instances, the oxygenabsorber maintains zero % oxygen level in the secondary packaging for atleast 36 months.

An advantageous feature of the oxygen absorber in the pharmaceuticalpackaging systems herein is the absorbance and removal of oxygen presentin the primary packaging and in the liquid drug itself. It was foundthat the oxygen absorber in exemplary packaging systems also removedresidual oxygen in the primary packaging and in the liquid over time tozero % oxygen level.

The oxygen absorber, in some embodiments, also maintains zero % oxygenlevel after removal of the initial oxygen in the primary packaging foran extended period of time. In some embodiments, the oxygen absorbermaintains zero % oxygen level in the primary packaging for the entireshelf life of the drug. In some embodiments, the oxygen absorbermaintains zero % oxygen level in the primary packaging for at leastabout 12 months, at least about 15 months, at least about 18 months, atleast about 24 months, at least about 30 months, at least about 36months, at least about 48 months, or at least about 60 months. Incertain instances, the oxygen absorber maintains zero % oxygen level inthe primary packaging for at least 12 months. In certain instances, theoxygen absorber maintains zero % oxygen level in the primary packagingfor at least 24 months. In certain instances, the oxygen absorbermaintains zero % oxygen level in the primary packaging for at least 36months.

An interesting property of the pharmaceutical packaging systems hereinis that after removal of oxygen in the primary and secondary packagingby the oxygen absorber, the air pressure in the secondary packagingenvironment achieves lower than atmospheric pressure, such that there isvacuum effect.

The capacity for absorbing oxygen for the oxygen absorbers of thepharmaceutical packaging systems described herein encompass thecapacities sufficient to reduce the initial oxygen levels of the primaryand secondary packaging to a zero % oxygen level at a rate as describedin the previous embodiments and maintain the zero % oxygen level for aperiod of time as described in the previous embodiments. The oxygenabsorbing capacity can be optimized according to the materials used insecondary packaging, the surface area of the secondary packaging andamount of initial oxygen in the secondary and primary packaging.

Referring to FIGS. 1-9, a syringe packaging system 10 includes apackaging member 12 formed of a generally oxygen impermeable materialand a sealing member 15 (FIG. 2B) which may be removably attached topackaging member 12. Packaging member 12 is sized and adapted to receiveeach of syringe barrel 14, plunger rod 16, and oxygen absorber 18therein as will be described in more detail below.

Sealing member 15 provides an additional mechanism to reduce oxygenlevels within packaging member 12 by sealing syringe barrel 14, plungerrod 16, and oxygen absorber 18 within packaging member 12 as will bedescribed in more detail below. In one embodiment, sealing member 15 maybe formed of an aluminum based material to provide sufficient sealingwith packaging member 12 as will be described below. In one embodiment,sealing member 15 may be formed of a generally oxygen impermeablematerial.

Referring to FIGS. 1-9, packaging member 12 is sized to receive syringebarrel 14, plunger rod 16, and oxygen absorber 18 therein. In oneembodiment, packaging member 12 defines a first compartment 100, asecond compartment 102, and a third compartment 104. The firstcompartment 100 is sized and adapted to receive syringe barrel 14therein, the second compartment 102 is sized and adapted to receiveplunger rod 16 therein, and the third compartment 104 is sized andadapted to receive oxygen absorber 18 therein. The first compartment100, the second compartment 102, and the third compartment 104 are ingaseous communication theretogether. In this manner, with the packagingmember 12 enclosing the syringe barrel 14, the plunger rod 16, and theoxygen absorber 18, the oxygen absorber 18 is adapted to draw oxygenfrom the syringe barrel 14 and to absorb oxygen contained within thefirst compartment 100, the second compartment 102, and the thirdcompartment 104 of the packaging member 12.

Referring to FIGS. 1-9, packaging member 12 includes a first or top end110, a second or bottom end 112, and a sidewall 114 extending betweentop end 110 and bottom end 112. Packaging member 12 includes a lockinglip 116 at top end 110. Disposed below locking lip 116 is an upper trayportion 118 having a cross-section that has a greater area than across-section disposed below upper tray portion 118, i.e., a compartmentportion 120, such that a shoulder 122 is defined therebetween. Uppertray portion 118 receives and supports flange 40 of syringe barrel 14and flange 74 of plunger rod 16 as will be described in more detailbelow. Referring to FIG. 5, in one embodiment, an interior surface 115of sidewall 114 of packaging member 12 defines opposing slots 124extending along a longitudinal axis of packaging member 12. Referring toFIGS. 3A, 5, and 9, interior surface 115 of sidewall 114 of packagingmember 12 includes opposing protrusions or locking ribs 126.

In one embodiment, packaging member 12 is formed of a generally oxygenimpermeable material or a high oxygen barrier material, i.e., a lowoxygen permeability material. For example, packaging member 12 may beformed of a polyester material or its derivative, a polyamide materialor its derivative, or a blend from an extremely high oxygen barrier suchas ethylene vinyl alcohol or similar material. In one embodiment,packaging member 12 may be formed of a single barrier material or acombination of barrier materials or multiple layers such that one ormore of the layers provide the necessary barrier while the others arenon-barrier materials providing necessary mechanical or other materialproperties. In one embodiment, multiple layers of the packaging member12 may be formed by co-injection or two-shot injection or blending of anactive oxygen material with a base resin, or a similar process with orwithout regard to the position of the barrier material or thenon-barrier materials in the overall packaging structure. In oneembodiment, the thickness of the packaging member 12 may be as low as0.2 mm and as high as 1.2 mm as long as it provides the necessarymechanical strength and the oxygen barrier requirement is fulfilled.

In one embodiment, the surface properties, e.g., the coefficient offriction, of the materials for the oxygen absorber 18 and the packagingmember 12 are such as to allow desirable and smooth movements betweenthe oxygen absorber 18 and the packaging member 12 without causing anydamage to any of the components of the syringe packaging system 10.

Referring to FIGS. 1-3B and 10-14, syringe packaging system 10 includesa partition member 130 that is receivable within the packaging member12. The partition member 130 includes a vertical wall 132 having a firstend 134 and a second end 136. The partition member 130 also includes ahorizontal wall 138 located at second end 136 of vertical wall 132. Inone embodiment, the vertical wall 132 and the horizontal wall 138together generally form a T-shape. The first end 134 of the verticalwall 132 of partition member 130 includes a flange 140. The horizontalwall 138 of partition member 130 defines a plurality of gas holes 142.Referring to FIGS. 10-12, the width of vertical wall 132 is greater thanthe width of horizontal wall 138. In this manner, a first sidewall 144and a second sidewall 146 of vertical wall 132 extend outward fromhorizontal wall 138 as shown in FIGS. 10-12.

All of the components of syringe packaging system 10 may be constructedof any known material, and are desirably constructed of medical-gradepolymers.

Referring to FIGS. 1-14, packaging of syringe barrel 14, plunger rod 16,and oxygen absorber 18 within packaging member 12 will now be described.Initially, syringe barrel 14, plunger rod 16, and packaging member 12are sterilized according to techniques known to those of ordinary skillin the art. In some embodiments, syringe barrel 14 may be pre-filled asdescribed above.

Next, oxygen absorber 18 is inserted into compartment portion 120 ofpackaging member 12 such that oxygen absorber 18 is positionedhorizontally within packaging member 12 adjacent bottom end 112 ofpackaging member 12 as shown in FIGS. 3A and 3B.

Next, partition member 130 is received within packaging member 12 asshown in FIGS. 2A-3B. To secure partition member 130 within packagingmember 12, first sidewall 144 and second sidewall 146 of vertical wall132 of partition member 130 are respectively positioned within opposingslots 124 of packaging member 12 and partition member 130 is inserted ormoved axially into packaging member 12 in a direction generally alongarrow A (FIG. 1). As additional force is exerted on partition member 130to axially move partition member 130 in the direction generally alongarrow A within packaging member 12, horizontal wall 138 of partitionmember 130 deforms locking ribs 126 of packaging member 12 outward untilhorizontal wall 138 of partition member 130 advances beyond, i.e.,slides over and past, locking ribs 126 of packaging member 12 and lockspartition member 130 to packaging member 12 as shown in FIGS. 3A and 3B.Once horizontal wall 138 of partition member 130 slides over and pastlocking ribs 126 of packaging member 12, locking ribs 126 return totheir undeformed or original position as shown in FIGS. 3A and 3B. Inthis position, referring to FIGS. 3A and 3B, locking ribs 126 abut,contact, or engage horizontal wall 138 of partition member 130 and lockor secure partition member 130 to packaging member 12. Thisconfiguration ensures that partition member 130 is secured to packagingmember 12, such that significant relative movement between partitionmember 130 and packaging member 12 is prevented. In this manner,partition member 130 and packaging member 12 define the firstcompartment 100, the second compartment 102, and the third compartment104. The first compartment 100 is sized and adapted to receive syringebarrel 14 therein, the second compartment 102 is sized and adapted toreceive plunger rod 16 therein, and the third compartment 104 is sizedand adapted to receive oxygen absorber 18 therein. The first compartment100, the second compartment 102, and the third compartment 104 are ingaseous communication theretogether. In one embodiment, gas holes 142 ofhorizontal wall 138 of partition member 130 provide gaseouscommunication between the third compartment 104 and the firstcompartment 100 and the second compartment 102. In this manner, with thepackaging member 12 enclosing the syringe barrel 14, the plunger rod 16,and the oxygen absorber 18, the oxygen absorber 18 is adapted to drawoxygen from the syringe barrel 14 and to absorb oxygen contained withinthe first compartment 100, the second compartment 102, and the thirdcompartment 104 of the packaging member 12.

Additionally, with partition member 130 secured to packaging member 12as described above, such that, significant relative movement betweenpartition member 130 and packaging member 12 is prevented, partitionmember 130 and packaging member 12 provide a third compartment 104 thatsecures oxygen absorber 18 within packaging member 12 such that oxygenabsorber 18 is prevented from being removed from packaging member 12.

Next, referring to FIGS. 1-3B, syringe barrel 14 is inserted into firstcompartment 100 of packaging member 12 such that flange 40 of syringebarrel 14 abuts upper tray portion 118 as shown in FIGS. 3A and 3B. Withsyringe barrel 14 properly inserted into first compartment 100 ofpackaging member 12, plunger rod 16 is then inserted into secondcompartment 102 of packaging member 12 as shown in FIGS. 3A and 3B. Inone embodiment, upper tray portion 118 of packaging member 12 mayinclude a plunger rod support member such that with plunger rod 16inserted into second compartment 102 of packaging member 12, flange 74of plunger rod 16 abuts flange 40 of syringe barrel 14 on one side andabuts the plunger rod support member on another side.

As discussed above, after syringe packaging system 10 is properlysterilized, at least a portion of syringe barrel 14 may be properlyinserted into first compartment 100 of packaging member 12; at least aportion of plunger rod 16 may be properly inserted into secondcompartment 102 of packaging member 12; and at least a portion of oxygenabsorber 18 may be properly inserted into third compartment 104 ofpackaging member 12. Next, sealing member 15 (FIG. 2B) is used tocooperate with first end 110 of packaging member 12 to seal syringebarrel 14, plunger rod 16, and oxygen absorber 18 within packagingmember 12, i.e., sealing member 15 and packaging member 12 togetherprovide a substantially impermeable enclosure which provides a leakprevention and protection enclosure, protects the contents of syringebarrel 14, plunger rod 16, and oxygen absorber 18 contained withinpackaging member 12, and/or maintains a sealed, sterilized environmentwithin packaging member 12. Additionally, sealing member 15 andpackaging member 12 together provide an additional mechanism to reduceoxygen levels within packaging member 12 by sealing syringe barrel 14,plunger rod 16, and oxygen absorber 18 within packaging member 12 toprevent oxygen external to syringe packaging system 10 from entering thesealed packaging member 12. Sealing member 15 and packaging member 12together provide a sufficient seal at a range of temperatures,pressures, and humidity levels.

As previously discussed, by disposing oxygen absorber 18 within thesealed packaging member 12, oxygen absorber 18 can reduce the oxygenlevels within packaging member 12 and remove oxygen contained in fluid F(FIG. 3B) disposed within chamber 36 of syringe barrel 14. Any oxygencontained within packaging member 12 will be absorbed by oxygen absorber18. Additionally, oxygen contained within chamber 36 of syringe barrel14, and/or oxygen contained in fluid F disposed within chamber 36 ofsyringe barrel 14, will flow from chamber 36 of syringe barrel 14 tooxygen absorber 18 via the portion of syringe barrel 14 that includes anoxygen permeable member as described above. Reduction of oxygen levelswithin packaging member 12 is important because atmospheric gases suchas oxygen contained in packaging member 12 and contained in the fluid Fdisposed within chamber 36 of syringe barrel 14 can cause fluid F, suchas a medication or drug in a pre-filled syringe, to degrade.

The syringe packaging system of the present disclosure also allows forreduced storage space of a syringe assembly. By having syringe assembly13 including plunger rod 16 separate and detached from syringe barrel14, plunger rod 16 and syringe barrel 14 can be separately placed inpackaging member 12 in a manner that allows for reduced storage space ofsyringe assembly 13. For example, a conventional pre-filled syringe istypically packaged with a plunger rod retracted out of a back orproximal end of a syringe barrel, with the fluid pre-filled within thesyringe barrel. Accordingly, packaging of such pre-filled syringes isbulky and awkward for shipping and storage. For example, the overalllength to be packaged of a conventional pre-filled syringe is equal tothe length of the syringe barrel and the length that the plunger rodextends outwardly from the syringe barrel. By having syringe assembly 13including plunger rod 16 separate and detached from syringe barrel 14,plunger rod 16 and syringe barrel 14 can be separately placed inpackaging member 12 as shown in FIGS. 3A and 3B in a manner that allowsfor reduced storage space of syringe assembly 13. In this manner, theoverall length to be packaged of a syringe assembly 13 of the presentdisclosure is equal to the length of the syringe barrel 14. Accordingly,a syringe assembly 13 in accordance with the present invention allowsplunger rod 16 and syringe barrel 14 to be packaged in a manner thatallows for reduced storage space.

Additionally, in accordance with a syringe assembly of the presentinvention, upon removal of plunger rod 16 and syringe barrel 14 frompackaging member 12, plunger rod 16 can quickly and easily be secured tosyringe barrel 14 for collecting a fluid and/or delivering a fluid.

Referring to FIGS. 3A and 3B, oxygen absorber 18 is positioned in thepackaging member 12 underneath plunger rod 16, i.e., oxygen absorber 18is positioned adjacent the closed bottom end 112 of packaging member 12and plunger rod 16 is positioned above the oxygen absorber 18 as shownin FIGS. 3A and 3B. For example, the third compartment 104 which issized and adapted to receive the oxygen absorber 18 therein is locatedunderneath the second compartment 102 which is sized and adapted toreceive the plunger rod 16 therein as shown in FIGS. 3A and 3B. In thismanner, upon removal of plunger rod 16 and syringe barrel 14 frompackaging member 12, oxygen absorber 18 is prevented from also beingremoved from packaging member 12. Referring to FIGS. 24-70, in otherexemplary embodiments of the present disclosure, the oxygen absorber 18is positioned in the packaging member underneath plunger rod 16, i.e.,oxygen absorber 18 is positioned adjacent the closed bottom end of thepackaging member and plunger rod 16 is positioned above the oxygenabsorber 18.

Referring to FIGS. 1-3B, 15, and 17-23, removal of syringe barrel 14 andplunger rod 16 from packaging member 12 so that syringe barrel 14 andplunger rod 16 can be secured together to form a syringe assembly toexpel a fluid, such as a medication, contained within chamber 36 ofsyringe barrel 14 will now be described. Initially, the user removessyringe barrel 14 and plunger rod 16 from packaging member 12. To removesyringe barrel 14 and plunger rod 16 from packaging member 12, in oneembodiment, a user can first check to make sure a tear strip or othertamper evidence member has not been broken. Next, the user can removethe tamper evidence member and then break the above described sealbetween sealing member 15 (FIG. 2B) and packaging member 12.

With the seal between sealing member 15 and packaging member 12 broken,a user can grasp flange 74 of plunger rod 16 and pull flange 74longitudinally to remove plunger rod 16 from second compartment 102 ofpackaging member 12. Next, a user can grasp flange 40 of syringe barrel14 located in upper tray portion 118 of packaging member 12 and pullflange 40 longitudinally to remove syringe barrel 14 from firstcompartment 100 of packaging member 12. With plunger rod 16 and syringebarrel 14 removed from packaging member 12, plunger rod 16 and syringebarrel 14 can be secured together to form syringe assembly 13 adaptedfor dispensing and delivery of a fluid and/or collection of a fluid.

As described above, with partition member 130 secured to packagingmember 12, such that significant relative movement between partitionmember 130 and packaging member 12 is prevented, partition member 130and packaging member 12 provide a third compartment 104 that securesoxygen absorber 18 within packaging member 12 such that oxygen absorber18 is prevented from being removed from packaging member 12 when syringebarrel 14 and plunger rod 16 are removed from packaging member 12.

Referring to FIGS. 17-23, an embodiment of a securement feature operableto secure plunger rod 16 to syringe barrel 14 via stopper adapter 21will now be described. With plunger rod head 78 of plunger rod 16positioned adjacent plunger receiving aperture 54 of stopper adapter 21,plunger rod 16 is inserted or moved axially into plunger receivingaperture 54 in a direction generally along arrow B (FIG. 17), such thatelastic fingers 80 of plunger rod head 78 are disposed within plungerreceiving aperture 54 of stopper adapter 21. As additional force isexerted on plunger rod 16 to axially move plunger rod head 78 in thedirection generally along arrow B within plunger receiving aperture 54,elastic fingers 80 cooperate with tapered portion 60 of protrudingannular ring 58 and protruding annular ring 58 pushes or compresseselastic fingers 80 of plunger rod head 78 inward in a directiongenerally along arrow C (FIG. 18A) until elastic fingers 80 of plungerrod head 78 slide over and past tapered portion 60 of protruding annularring 58 and lock plunger rod 16 to stopper adapter 21 as shown in FIGS.18A and 18B. Once elastic fingers 80 of plunger rod head 78 slide overand past tapered portion 60 of protruding annular ring 58, elasticfingers 80 return to their original position as shown in FIGS. 17 and18A. In this position, referring to FIG. 18A, locking end 62 ofprotruding annular ring 58 abuts, contacts, or engages locking end 88 ofelastic fingers 80 with protruding annular ring 58 disposed adjacentannular groove 84 of plunger rod head 78 and locks or secures plungerrod 16 to stopper adapter 21. This configuration ensures that withelastic fingers 80 mechanically locked over protruding annular ring 58,plunger rod 16 is secured to stopper adapter 21, such that significantrelative movement between plunger rod 16 and stopper adapter 21 isprevented. In this manner, plunger rod 16 is adapted for advancingstopper 19 within syringe barrel 14.

In another embodiment, the engagement portion 56 of stopper adapter 21may include a deformable restraining member, e.g., elastic fingers, andthe engagement portion 76 of plunger rod 16 may include a plunger rodhead 78 formed of a rigid, unyielding material for securing plunger rod16 to stopper adapter 21. In another alternative embodiment, plunger rod16 can be secured to syringe barrel 14 via stopper adapter 21 bythreadingly engaging a threaded portion of plunger rod 16 to a threadedportion of stopper adapter 21. In other embodiments, plunger rod 16 canbe secured to stopper adapter 21 using a ball detent, locking tabs,spring loaded locking mechanism, latch, adhesive, or other similarmechanism. In all embodiments, plunger rod 16 is locked, secured, orengaged to stopper adapter 21, i.e., significant relative movementbetween plunger rod 16 and stopper adapter 21 is prevented and movementof plunger rod 16 can be transferred to stopper 19 to slide stopper 19between positions within syringe barrel 14. In other alternateembodiments, plunger rod 16 and stopper adapter 21 may be integrallyformed and both form a plunger assembly positioned within secondcompartment 102 of packaging member 12 and the separate syringe barrel14 positioned within first compartment 100 of packaging member 12.

In other embodiments, plunger rod 16 and stopper adapter 21 may beco-formed such as by co-extrusion. In alternate embodiments, plunger rod16 and stopper adapter 21 may be integrally formed as a plunger assemblythat is securable to syringe barrel 14.

Next, referring to FIGS. 21-23, with plunger rod 16 and syringe barrel14 secured together to form syringe assembly 13, a user can removesealing cap member 42 from distal end 32 of syringe barrel 14. A usercan then attach distal end 32 of syringe barrel 14 to a separate needleassembly or IV connection assembly and lockingly engage the needleassembly or IV connection assembly to distal end 32 of syringe barrel 14in a known manner. Prior to dispensing any medication, any gas or airtrapped within chamber 36 of syringe barrel 14 can be expelled in aknown manner.

Referring to FIGS. 21-23, the use of syringe assembly 13 to expel afluid, such as a medication, contained within chamber 36 of syringebarrel 14 will now be described. Movement of flange 74 of plunger rod 16provides actuation means for moving or sliding stopper 19 betweenpositions within syringe barrel 14. For example, flange 74 may have anyshape that allows a user to grip and actuate flange 74 of plunger rod 16in a back and forth direction.

When it is desired to expel or deliver the medication contained withinsyringe barrel 14, syringe assembly 13 is grasped with the user's thumbon flange 74 of plunger rod 16 and with the user's fingers grasping andextending around flange 40 of syringe barrel 14. In this manner, syringeassembly 13 is grasped by a user in a well-known and well recognizedmanner similar to the operation of a conventional hypodermic syringe.Next, the user effects a squeezing movement between the thumb on flange74 of plunger rod 16 and four fingers grasping flange 40 of syringebarrel 14, thereby causing flange 74 of plunger rod 16 to move in adirection generally along arrow D (FIG. 23) toward proximal end 34 ofsyringe barrel 14. In this manner, movement of stopper 19 in thedirection generally along arrow D forces the fluid F (FIG. 3B) containedwithin chamber 36 of syringe barrel 14 to be forced out outlet opening38, i.e., movement of stopper 19 towards distal end 32 of syringe barrel14 reduces the volume of chamber 36 and forces the fluid F from syringebarrel 14. The fluid F can be expelled from syringe barrel 14 throughoutlet opening 38 for contact with a patient and/or into a separateneedle assembly or IV assembly and into the patient.

Referring now to FIGS. 21-23, the use of syringe assembly 13 to fillsyringe barrel 14 with medication from a separate vial prior to use willnow be described. With syringe assembly 13 in a position in whichstopper 19 is located adjacent distal end 32 of syringe barrel 14 andwith a needle assembly locked to distal end 32 of syringe barrel 14 andplaced in a vial containing fluid, when it is desired to aspirate orpull the fluid, such as a medication, into chamber 36 of syringe barrel14, a user moves flange 74 of plunger rod 16 in a direction generallyalong arrow E (FIG. 23) and away from proximal end 34 of syringe barrel14 until the desired amount of the fluid is pulled into chamber 36 ofsyringe barrel 14.

In this manner, movement of stopper 19 in the direction generally alongarrow E creates a vacuum inside chamber 36 of syringe barrel 14. As theuser moves stopper 19, via plunger rod 16 in the direction generallyalong arrow E, the user actively increases the volume within chamber 36of syringe barrel 14. Because the stopper is sized relative to syringebarrel 14 to provide sealing engagement with the interior wall ofsyringe barrel 14, as described above, and because the needle assemblylocked to distal end 32 of syringe barrel 14 is placed in a vialcontaining fluid, no gas or air can enter into chamber 36 of syringebarrel 14 and, thus, the same number of gas or air molecules are locatedwithin chamber 36 as the user actively increases the volume withinchamber 36. This decreases the pressure in chamber 36 of syringe barrel14 relative to the air pressure outside of syringe barrel 14. Therefore,a vacuum, i.e., a space of lower air pressure, is created to pull thefluid, such as a medication, into chamber 36 of syringe barrel 14.Advantageously, syringe assembly 13 can be used to collect a fluid intochamber 36 of syringe barrel 14 or to expel a fluid out of chamber 36 ofsyringe barrel 14.

FIGS. 24-33 illustrate another exemplary embodiment of the presentdisclosure. Referring to FIGS. 24-33, a syringe packaging system 10Aincludes a packaging member 12A, a syringe assembly 13 including asyringe barrel 14 and a detachable plunger rod 16, an oxygen absorber18, and a stopper 19. With the packaging member 12A enclosing thesyringe barrel 14, the plunger rod 16, and the oxygen absorber 18, theoxygen absorber 18 is adapted to draw oxygen from the syringe barrel 14and to absorb oxygen contained within the packaging member 12A. Thesyringe packaging system 10A of the present disclosure also allows forreduced storage space of a syringe assembly.

The exemplary embodiment illustrated in FIGS. 24-33 includes similarcomponents to the embodiment illustrated in FIGS. 1-9. For the sake ofbrevity, these similar components and the similar steps of using syringepackaging system 10A will not all be discussed in conjunction with theembodiment illustrated in FIGS. 24-33. In one embodiment, syringepackaging system 10A is compatible with the syringe assembly 13 and theoxygen absorber 18 shown in FIGS. 15-23.

Referring to FIGS. 24-33, a syringe packaging system 10A includes apackaging member 12A formed of a generally oxygen impermeable material.In one embodiment, a sealing member 15 (FIG. 2B) may be removablyattached to packaging member 12A. Packaging member 12A is sized andadapted to receive each of syringe barrel 14, plunger rod 16, and oxygenabsorber 18 therein as will be described in more detail below.

Referring to FIGS. 24-33, packaging member 12A includes a firstcompartment 100A, a second compartment 102A, a third compartment 104A, afirst or top end 110A, a second or bottom end 112A, and a sidewall 114Aextending between top end 110A and bottom end 112A. Packaging member 12Aincludes a locking lip 116A at top end 110A. Disposed below locking lip116A is an upper tray portion 118A having a cross-section that has agreater area than a cross-section disposed below upper tray portion118A, i.e., a compartment portion 120A, such that a shoulder 122A isdefined therebetween. The compartment portion 120A includes a separatorwall 150 disposed therein such that separator wall 150 dividescompartment portion 120A into first compartment 100A and secondcompartment 102A. The separator wall 150 defines a gas slot 152 whichmaintains first compartment 100A and second compartment 102A in gaseouscommunication theretogether. The second compartment 102A includes afirst bump 154 and a second bump 156 spaced from first bump 154. In oneembodiment, first bump 154 and second bump 156 are molded on an interiorsurface 115A of sidewall 114A of packaging member 12A.

Referring to FIG. 30, syringe packaging system 10A includes a partitionmember 160 that is receivable within the packaging member 12A. Thepartition member 160 includes opposing notches 162 and defines aplurality of gas holes 164.

All of the components of syringe packaging system 10A may be constructedof any known material, and are desirably constructed of medical-gradepolymers.

Referring to FIGS. 24-33, packaging of syringe barrel 14, plunger rod16, and oxygen absorber 18 within packaging member 12A will now bedescribed. Initially, syringe barrel 14, plunger rod 16, and packagingmember 12A are sterilized according to techniques known to those ofordinary skill in the art as described above. In some embodiments,syringe barrel 14 may be pre-filled as described above. Next, oxygenabsorber 18 is inserted into the third compartment 104A side ofcompartment portion 120A of packaging member 12A such that oxygenabsorber 18 is positioned vertically within packaging member 12Aadjacent bottom end 112A of packaging member 12A on the thirdcompartment 104A side as shown in FIG. 31.

Next, partition member 160 is received within packaging member 12A asshown in FIGS. 31 and 33. To secure partition member 160 withinpackaging member 12A, partition member 160 is positioned within thesecond compartment 102A side of compartment portion 120A and partitionmember 160 is inserted or moved axially into packaging member 12A in adirection generally along arrow A (FIG. 1). In one embodiment, notches162 of partition member 160 provide a feature to hold during placementof partition member 160 within packaging member 12A. As additional forceis exerted on partition member 160 to axially move partition member 160in the direction generally along arrow A within packaging member 12A,partition member 160 deforms first bump 154 of packaging member 12Aoutward until partition member 160 advances beyond, i.e., slides overand past, first bump 154 of packaging member 12A and locks partitionmember 160 between first bump 154 and second bump 156 as shown in FIGS.31 and 33. Once partition member 160 slides over and past first bump 154of packaging member 12A, first bump 154 returns to its undeformed ororiginal position. In this position, referring to FIGS. 31 and 33, firstbump 154 and second bump 156 abut, contact, or engage partition member160 and lock or secure partition member 160 to packaging member 12Abetween first bump 154 and second bump 156 as shown in FIGS. 31 and 33.This configuration ensures that partition member 160 is secured topackaging member 12A, such that significant relative movement betweenpartition member 160 and packaging member 12A is prevented. In thismanner, partition member 160 and packaging member 12A define the secondcompartment 102A and the third compartment 104A. The first compartment100A is sized and adapted to receive syringe barrel 14 therein, thesecond compartment 102A is sized and adapted to receive plunger rod 16therein, and the third compartment 104A is sized and adapted to receiveoxygen absorber 18 therein. The first compartment 100A, the secondcompartment 102A, and the third compartment 104A are in gaseouscommunication theretogether. In one embodiment, gas holes 164 ofpartition member 160 and gas slot 152 of separator wall 150 providegaseous communication between the compartments 100A, 102A, and 104A. Inthis manner, with the packaging member 12A enclosing the syringe barrel14, the plunger rod 16, and the oxygen absorber 18, the oxygen absorber18 is adapted to draw oxygen from the syringe barrel 14 and to absorboxygen contained within the first compartment 100A, the secondcompartment 102A, and the third compartment 104A of the packaging member12A.

Additionally, with partition member 160 secured to packaging member 12Aas described above, such that significant relative movement betweenpartition member 160 and packaging member 12A is prevented, partitionmember 160 and packaging member 12A provide a third compartment 104Athat secures oxygen absorber 18 within packaging member 12A such thatoxygen absorber 18 is prevented from being removed from packaging member12A.

Next, syringe barrel 14 is inserted into first compartment 100A ofpackaging member 12A as described above. With syringe barrel 14 properlyinserted into first compartment 100A of packaging member 12A, plungerrod 16 is then inserted into second compartment 102A of packaging member12A as described above.

As discussed above, after syringe packaging system 10A is properlysterilized, at least a portion of syringe barrel 14 may be properlyinserted into first compartment 100A of packaging member 12A; at least aportion of plunger rod 16 may be properly inserted into secondcompartment 102A of packaging member 12A; and at least a portion ofoxygen absorber 18 may be properly inserted into third compartment 104Aof packaging member 12A. Next, sealing member 15 (FIG. 2B) is used tocooperate with packaging member 12A to seal syringe barrel 14, plungerrod 16, and oxygen absorber 18 within packaging member 12A, i.e.,sealing member 15 and packaging member 12A together provide asubstantially impermeable enclosure which provides a leak prevention andprotection enclosure, protects the contents of syringe barrel 14,plunger rod 16, and oxygen absorber 18 contained within packaging member12A, and/or maintains a sealed, sterilized environment within packagingmember 12A. Additionally, sealing member 15 and packaging member 12Atogether provide an additional mechanism to reduce oxygen levels withinpackaging member 12A by sealing syringe barrel 14, plunger rod 16, andoxygen absorber 18 within packaging member 12A to prevent oxygenexternal to syringe packaging system 10A from entering the sealedpackaging member 12A. Sealing member 15 and packaging member 12Atogether provide a sufficient seal at a range of temperatures,pressures, and humidity levels.

FIGS. 34-44 illustrate another exemplary embodiment of the presentdisclosure. Referring to FIGS. 15-23 and 34-44, a syringe packagingsystem 10B includes a packaging member 12B, a syringe assembly 13including a syringe barrel 14 and a detachable plunger rod 16, an oxygenabsorber 18, a stopper 19, and a stopper adapter 21. With the packagingmember 12B enclosing the syringe barrel 14, the plunger rod 16, and theoxygen absorber 18, the oxygen absorber 18 is adapted to draw oxygenfrom the syringe barrel 14 and to absorb oxygen contained within thepackaging member 12B. The syringe packaging system 10B of the presentdisclosure also allows for reduced storage space of a syringe assembly.

The exemplary embodiment illustrated in FIGS. 34-44 includes similarcomponents to the embodiment illustrated in FIGS. 1-9. For the sake ofbrevity, these similar components and the similar steps of using syringepackaging system 10B will not all be discussed in conjunction with theembodiment illustrated in FIGS. 34-44. In one embodiment, syringepackaging system 10B is compatible with the syringe assembly 13 and theoxygen absorber 18 shown in FIGS. 15-23.

Referring to FIGS. 34-44, a syringe packaging system 10B includes apackaging member 12B formed of a generally oxygen impermeable material.In one embodiment, a sealing member 15 (FIG. 2B) may be removablyattached to packaging member 12B. Packaging member 12B is sized andadapted to receive each of syringe barrel 14, plunger rod 16, and oxygenabsorber 18 therein as will be described in more detail below.

Referring to FIGS. 34-44, packaging member 12B includes a firstcompartment 100B, a second compartment 102B, a third compartment 104B, afirst or top end 110B, a second or bottom end 112B, and a sidewall 114Bextending between top end 110B and bottom end 112B. Packaging member 12Bincludes a locking lip 116B at top end 110B. Disposed below locking lip116B is an upper tray portion 118B having a cross-section that has agreater area than a cross-section disposed below upper tray portion118B, i.e., a compartment portion 120B, such that a shoulder 122B isdefined therebetween. The compartment portion 120B includes a separatorwall 170 disposed therein such that separator wall 170 dividescompartment portion 120B into first compartment 100B and secondcompartment 102B. The separator wall 170 defines a gas slot 172 whichmaintains first compartment 100B and second compartment 102B in gaseouscommunication theretogether. The second compartment 102B includes aninternal wall or oxygen absorber chamber 174 adjacent bottom end 112B ofpackaging member 12B. Oxygen absorber chamber 174 forms thirdcompartment 104B sized and adapted to receive the oxygen absorber 18therein. In one embodiment, the first compartment 100B, the secondcompartment 102B, and the third compartment 104B of packaging member 12Bare formed as a unitary packaging member component or compartment.

Referring to FIGS. 39-44, syringe packaging system 10B includes a lid176 that is receivable within the oxygen absorber chamber 174 ofpackaging member 12B. The lid 176 defines an aperture 178. In oneembodiment, lid 176 is sized and adapted to be securable to oxygenabsorber chamber 174 by an interference fit. The aperture 178 of lid 176provides for efficient performance of the oxygen absorber 18 containedwithin oxygen absorber chamber 174 and maintains the first compartment100B, the second compartment 102B, and the third compartment 104B ingaseous communication theretogether.

All of the components of syringe packaging system 10B may be constructedof any known material, and are desirably constructed of medical-gradepolymers.

Referring to FIGS. 34-44, packaging of syringe barrel 14, plunger rod16, and oxygen absorber 18 within packaging member 12B will now bedescribed. Initially, syringe barrel 14, plunger rod 16, and packagingmember 12B are sterilized according to techniques known to those ofordinary skill in the art as described above. In some embodiments,syringe barrel 14 may be pre-filled as described above. Next, oxygenabsorber 18 is inserted into the third compartment 104B of packagingmember 12B, i.e., oxygen absorber chamber 174, such that oxygen absorber18 is positioned vertically within oxygen absorber chamber 174 as shownin FIG. 44.

Next, lid 176 is secured to oxygen absorber chamber 174 using aninterference fit as shown in FIG. 44. This configuration ensures thatlid 176 is secured to oxygen absorber chamber 174, such that significantrelative movement between lid 176 and oxygen absorber chamber 174 isprevented. In this manner, lid 176 and oxygen absorber chamber 174define the second compartment 102B and the third compartment 104B. Thefirst compartment 100B is sized and adapted to receive syringe barrel 14therein, the second compartment 102B is sized and adapted to receiveplunger rod 16 therein, and the third compartment 104B is sized andadapted to receive oxygen absorber 18 therein. The first compartment100B, the second compartment 102B, and the third compartment 104B are ingaseous communication theretogether. In this manner, with the packagingmember 12B enclosing the syringe barrel 14, the plunger rod 16, and theoxygen absorber 18, the oxygen absorber 18 is adapted to draw oxygenfrom the syringe barrel 14 and to absorb oxygen contained within thefirst compartment 100B, the second compartment 102B, and the thirdcompartment 104B of the packaging member 12B.

Additionally, with lid 176 secured to oxygen absorber chamber 174 asdescribed above, such that significant relative movement between lid 176and oxygen absorber chamber 174 is prevented, lid 176 and oxygenabsorber chamber 174 provide a third compartment 104B that securesoxygen absorber 18 within packaging member 12B such that oxygen absorber18 is prevented from being removed from packaging member 12B.

Next, syringe barrel 14 is inserted into first compartment 100B ofpackaging member 12B as described above. With syringe barrel 14 properlyinserted into first compartment 100B of packaging member 12B, plungerrod 16 is then inserted into second compartment 102B of packaging member12B as described above.

As discussed above, after syringe packaging system 10B is properlysterilized, at least a portion of syringe barrel 14 may be properlyinserted into first compartment 100B of packaging member 12B; at least aportion of plunger rod 16 may be properly inserted into secondcompartment 102B of packaging member 12B; and at least a portion ofoxygen absorber 18 may be properly inserted into third compartment 104Bof packaging member 12B. Next, sealing member 15 (FIG. 2B) is used tocooperate with packaging member 12B to seal syringe barrel 14, plungerrod 16, and oxygen absorber 18 within packaging member 12B, i.e.,sealing member 15 and packaging member 12B together provide asubstantially impermeable enclosure which provides a leak prevention andprotection enclosure, protects the contents of syringe barrel 14,plunger rod 16, and oxygen absorber 18 contained within packaging member12B, and/or maintains a sealed, sterilized environment within packagingmember 12B. Additionally, sealing member 15 and packaging member 12Btogether provide an additional mechanism to reduce oxygen levels withinpackaging member 12B by sealing syringe barrel 14, plunger rod 16, andoxygen absorber 18 within packaging member 12B to prevent oxygenexternal to syringe packaging system 10B from entering the sealedpackaging member 12B. Sealing member 15 and packaging member 12Btogether provide a sufficient seal at a range of temperatures,pressures, and humidity levels.

FIGS. 45-53 illustrate another exemplary embodiment of the presentdisclosure. Referring to FIGS. 15-23 and 45-53, a syringe packagingsystem 10C includes a packaging member 12C, a syringe assembly 13including a syringe barrel 14 and a detachable plunger rod 16, an oxygenabsorber 18, a stopper 19, and a stopper adapter 21. With the packagingmember 12C enclosing the syringe barrel 14, the plunger rod 16, and theoxygen absorber 18, the oxygen absorber 18 is adapted to draw oxygenfrom the syringe barrel 14 and to absorb oxygen contained within thepackaging member 12C. The syringe packaging system 10C of the presentdisclosure also allows for reduced storage space of a syringe assembly.

The exemplary embodiment illustrated in FIGS. 45-53 includes similarcomponents to the embodiment illustrated in FIGS. 1-9. For the sake ofbrevity, these similar components and the similar steps of using syringepackaging system 10C will not all be discussed in conjunction with theembodiment illustrated in FIGS. 45-53. In one embodiment, syringepackaging system 10C is compatible with the syringe assembly 13 and theoxygen absorber 18 shown in FIGS. 15-23.

Referring to FIGS. 45-53, a syringe packaging system 10C includes apackaging member 12C formed of a generally oxygen impermeable material.In one embodiment, a sealing member 15 (FIG. 2B) may be removablyattached to packaging member 12C. Packaging member 12C is sized andadapted to receive each of syringe barrel 14, plunger rod 16, and oxygenabsorber 18 therein as will be described in more detail below.

Referring to FIGS. 45-53, packaging member 12C includes a firstcompartment 100C, a second compartment 102C, a third compartment 104C, afirst or top end 110C, a second or bottom end 112C, and a sidewall 114Cextending between top end 110C and bottom end 112C. Packaging member 12Cincludes a locking lip 116C at top end 110C. Disposed below locking lip116C is an upper tray portion 118C having a cross-section that has agreater area than a cross-section disposed below upper tray portion118C, i.e., a compartment portion 120C, such that a shoulder 122C isdefined therebetween. Upper tray portion 118C receives and supportsflange 40 of syringe barrel 14 and flange 74 of plunger rod 16 as willbe described in more detail below. An interior surface of sidewall 114Cof packaging member 12C includes opposing angled ribs 180 extendingalong a longitudinal axis of packaging member 12C. The opposing angledribs 180 define peaks 182 as shown in FIG. 50.

In one embodiment, the angled ribs 180 divide compartment portion 120Cinto the first compartment 100C and the second compartment 102C as shownin FIG. 46. In one embodiment, the peaks 182 of the angled ribs 180divide compartment portion 120C into the second compartment 102C and thethird compartment 104C as shown in FIG. 50. The first compartment 100C,the second compartment 102C, and the third compartment 104C are ingaseous communication theretogether. In one embodiment, the firstcompartment 100C, the second compartment 102C, and the third compartment104C of packaging member 12C are formed as a unitary packaging membercomponent or compartment.

Referring to FIGS. 45 and 46, upper tray portion 118C includes plungerrod support members 184 around a periphery of second compartment 102Cand syringe barrel support members 186 around a periphery of firstcompartment 100C. Plunger rod support members 184 provide a furthersecurement mechanism for engaging the plunger rod 16 to secure theplunger rod 16 within second compartment 102C of packaging member 12C.For example, referring to FIGS. 51 and 52, in one embodiment, as plungerrod 16 is inserted into second compartment 102C, the underside surfaceof flange 74 of plunger rod 16 engages plunger rod support members 184to secure plunger rod 16 within packaging member 12C in a stable manner.Syringe barrel support members 186 provide a further securementmechanism for engaging the syringe barrel 14 to secure the syringebarrel 14 within first compartment 100C of packaging member 12C. Forexample, referring to FIGS. 51 and 52, in one embodiment, as syringebarrel 14 is inserted into first compartment 100C, the flange 40 ofsyringe barrel 14 engages syringe barrel support members 186 to securesyringe barrel 14 within packaging member 12C. In one embodiment,syringe barrel support members 186 provide a mechanism that allows thesyringe barrel 14 to be positioned within packaging member 12C such thatthe flat end of flange 40 can be along one direction. In one embodiment,syringe barrel support members 186 serve as an anti-nesting mechanismduring bulk packaging.

Referring to FIGS. 45 and 46, the bottom portion or bottom end 112C ofpackaging member 12C tapers from third compartment 104C side to firstcompartment 100C side. In this manner, the overall size of packagingmember 12C is reduced.

All of the components of syringe packaging system 10C may be constructedof any known material, and are desirably constructed of medical-gradepolymers.

Referring to FIGS. 45-53, packaging of syringe barrel 14, plunger rod16, and oxygen absorber 18 within packaging member 12C will now bedescribed. Initially, syringe barrel 14, plunger rod 16, and packagingmember 12C are sterilized according to techniques known to those ofordinary skill in the art as described above. In some embodiments,syringe barrel 14 may be pre-filled as described above.

Next, oxygen absorber 18 is received within third compartment 104C ofpackaging member 12C such that oxygen absorber 18 is positionedvertically within third compartment 104C as shown in FIG. 53. To secureoxygen absorber 18 within third compartment 104C of packaging member12C, oxygen absorber 18 is inserted or moved axially into packagingmember 12C in a direction generally along arrow A (FIG. 1). Asadditional force is exerted on oxygen absorber 18 to axially move oxygenabsorber 18 in the direction generally along arrow A within packagingmember 12C, oxygen absorber 18 deforms peaks 182 of angled ribs 180 ofpackaging member 12C outward until oxygen absorber 18 advances beyond,i.e., slides over and past, peaks 182 of angled ribs 180 of packagingmember 12C and locks oxygen absorber 18 within third compartment 104C ofpackaging member 12C as shown in FIG. 53. Once oxygen absorber 18 slidesover and past peaks 182 of angled ribs 180 of packaging member 12C,peaks 182 of angled ribs 180 return to their undeformed or originalposition. In this position, peaks 182 of angled ribs 180 may abut,contact, or engage oxygen absorber 18 and lock or secure oxygen absorber18 within third compartment 104C of packaging member 12C. Thisconfiguration ensures that packaging member 12C provides a thirdcompartment 104C that secures oxygen absorber 18 within packaging member12C such that oxygen absorber 18 is prevented from being removed frompackaging member 12C. This configuration also ensures that the oxygenabsorber 18 is maintained within the third compartment 104C and is notable to slide towards the first compartment 100C.

Syringe packaging system 10C provides a system that has minimal or nointerference between packaging member 12C and oxygen absorber 18 onceoxygen absorber 18 is properly positioned within third compartment 104C.In this manner, there is very minimal or no stress exerted on thepackaging member 12C and/or the oxygen absorber 18.

Next, syringe barrel 14 is inserted into first compartment 100C ofpackaging member 12C as described above. With syringe barrel 14 properlyinserted into first compartment 100C of packaging member 12C, plungerrod 16 is then inserted into second compartment 102C of packaging member12C as described above.

In this manner, with the packaging member 12C enclosing the syringebarrel 14, the plunger rod 16, and the oxygen absorber 18, the oxygenabsorber 18 is adapted to draw oxygen from the syringe barrel 14 and toabsorb oxygen contained within the first compartment 100C, the secondcompartment 102C, and the third compartment 104C of the packaging member12C.

As discussed above, after syringe packaging system 10C is properlysterilized, at least a portion of syringe barrel 14 may be properlyinserted into first compartment 100C of packaging member 12C; at least aportion of plunger rod 16 may be properly inserted into secondcompartment 102C of packaging member 12C; and at least a portion ofoxygen absorber 18 may be properly inserted into third compartment 104Cof packaging member 12C. Next, sealing member 15 (FIG. 2B) is used tocooperate with packaging member 12C to seal syringe barrel 14, plungerrod 16, and oxygen absorber 18 within packaging member 12C, i.e.,sealing member 15 and packaging member 12C together provide asubstantially impermeable enclosure which provides a leak prevention andprotection enclosure, protects the contents of syringe barrel 14,plunger rod 16, and oxygen absorber 18 contained within packaging member12C, and/or maintains a sealed, sterilized environment within packagingmember 12C. Additionally, sealing member 15 and packaging member 12Ctogether provide an additional mechanism to reduce oxygen levels withinpackaging member 12C by sealing syringe barrel 14, plunger rod 16, andoxygen absorber 18 within packaging member 12C to prevent oxygenexternal to syringe packaging system 10C from entering the sealedpackaging member 12C. Sealing member 15 and packaging member 12Ctogether provide a sufficient seal at a range of temperatures,pressures, and humidity levels.

FIGS. 54-61 illustrate another exemplary embodiment of the presentdisclosure. Referring to FIGS. 15-23 and 54-61, a syringe packagingsystem 10D includes a packaging member 12D, a syringe assembly 13including a syringe barrel 14 and a detachable plunger rod 16, an oxygenabsorber 18, a stopper 19, and a stopper adapter 21. With the packagingmember 12D enclosing the syringe barrel 14, the plunger rod 16, and theoxygen absorber 18, the oxygen absorber 18 is adapted to draw oxygenfrom the syringe barrel 14 and to absorb oxygen contained within thepackaging member 12D. The syringe packaging system 10D of the presentdisclosure also allows for reduced storage space of a syringe assembly.

The exemplary embodiment illustrated in FIGS. 54-61 includes similarcomponents to the embodiment illustrated in FIGS. 1-9. For the sake ofbrevity, these similar components and the similar steps of using syringepackaging system 10D will not all be discussed in conjunction with theembodiment illustrated in FIGS. 54-61. In one embodiment, syringepackaging system 10D is compatible with the syringe assembly 13 and theoxygen absorber 18 shown in FIGS. 15-23.

Referring to FIGS. 54-61, a syringe packaging system 10D includes apackaging member 12D formed of a generally oxygen impermeable material.In one embodiment, a sealing member 15 (FIG. 2B) may be removablyattached to packaging member 12D. Packaging member 12D is sized andadapted to receive each of syringe barrel 14, plunger rod 16, and oxygenabsorber 18 therein as will be described in more detail below.

Referring to FIGS. 54-61, packaging member 12D includes a firstcompartment 100D, a second compartment 102D, a third compartment 104D, afirst or top end 110D, a second or bottom end 112D, and a sidewall 114Dextending between top end 110D and bottom end 112D. Packaging member 12Dincludes a locking lip 116D at top end 110D. Disposed below locking lip116D is an upper tray portion 118D having a cross-section that has agreater area than a cross-section disposed below upper tray portion118D, i.e., a compartment portion 120D, such that a shoulder 122D isdefined therebetween. Upper tray portion 118D receives and supportsflange 40 of syringe barrel 14 and flange 74 of plunger rod 16. Aninterior surface of sidewall 114D of packaging member 12D includesopposing fin elements 190 extending along a longitudinal axis ofpackaging member 12D. The opposing fin elements 190 include a lead-inportion 192, a top portion 194, and a bottom portion 196.

In one embodiment, the fin elements 190 divide compartment portion 120Dinto the first compartment 100D and the second compartment 102D as shownin FIG. 55. In one embodiment, the top portion 194 and bottom portion196 of fin elements 190 divide compartment portion 120D into the secondcompartment 102D and the third compartment 104D as shown in FIG. 57. Thefirst compartment 100D, the second compartment 102D, and the thirdcompartment 104D are in gaseous communication theretogether. In oneembodiment, the first compartment 100D, the second compartment 102D, andthe third compartment 104D of packaging member 12D are formed as aunitary packaging member component or compartment.

Referring to FIGS. 54 and 55, the bottom portion or bottom end 112D ofpackaging member 12D tapers from third compartment 104D side to firstcompartment 100D side. In this manner, the overall size of packagingmember 12D is reduced.

All of the components of syringe packaging system 10D may be constructedof any known material, and are desirably constructed of medical-gradepolymers.

Referring to FIGS. 54-61, packaging of syringe barrel 14, plunger rod16, and oxygen absorber 18 within packaging member 12D will now bedescribed. Initially, syringe barrel 14, plunger rod 16, and packagingmember 12D are sterilized according to techniques known to those ofordinary skill in the art as described above. In some embodiments,syringe barrel 14 may be pre-filled as described above.

Next, oxygen absorber 18 is received within third compartment 104D ofpackaging member 12D such that oxygen absorber 18 is positionedvertically within third compartment 104D. To secure oxygen absorber 18within third compartment 104D of packaging member 12D, oxygen absorber18 is inserted or moved axially into packaging member 12D in a directiongenerally along arrow A (FIG. 1). The lead-in portion 192 of finelements 190 provide a lead-in surface that helps with guiding andcentering oxygen absorber 18 within packaging member 12D. As additionalforce is exerted on oxygen absorber 18 to axially move oxygen absorber18 in the direction generally along arrow A within packaging member 12D,oxygen absorber 18 deforms a portion of fin elements 190 outward untiloxygen absorber 18 advances beyond, i.e., slides over and past, the topportion 194 of fin elements 190 of packaging member 12D and locks oxygenabsorber 18 within third compartment 104D of packaging member 12D. Onceoxygen absorber 18 slides over and past top portion 194 of fin elements190 of packaging member 12D, fin elements 190 return to their undeformedor original position. In this position, fin elements 190 may abut,contact, or engage oxygen absorber 18 and lock or secure oxygen absorber18 within third compartment 104D of packaging member 12D by aninterference fit between fin elements 190 and oxygen absorber 18. Thisconfiguration ensures that packaging member 12D provides a thirdcompartment 104D that secures oxygen absorber 18 within packaging member12D such that oxygen absorber 18 is prevented from being removed frompackaging member 12D. This configuration also ensures that the oxygenabsorber 18 is maintained within the third compartment 104D and is notable to slide towards the first compartment 100D.

Next, syringe barrel 14 is inserted into first compartment 100D ofpackaging member 12D as described above. With syringe barrel 14 properlyinserted into first compartment 100D of packaging member 12D, plungerrod 16 is then inserted into second compartment 102D of packaging member12D as described above.

In this manner, with the packaging member 12D enclosing the syringebarrel 14, the plunger rod 16, and the oxygen absorber 18, the oxygenabsorber 18 is adapted to draw oxygen from the syringe barrel 14 and toabsorb oxygen contained within the first compartment 100D, the secondcompartment 102D, and the third compartment 104D of the packaging member12D.

FIGS. 62-70 illustrate another exemplary embodiment of the presentdisclosure. Referring to FIGS. 15-23 and 62-70, a syringe packagingsystem 10E includes a packaging member 12E, a syringe assembly 13including a syringe barrel 14 and a detachable plunger rod 16, an oxygenabsorber 18, a stopper 19, and a stopper adapter 21. With the packagingmember 12E enclosing the syringe barrel 14, the plunger rod 16, and theoxygen absorber 18, the oxygen absorber 18 is adapted to draw oxygenfrom the syringe barrel 14 and to absorb oxygen contained within thepackaging member 12E. The syringe packaging system 10E of the presentdisclosure also allows for reduced storage space of a syringe assembly.

The exemplary embodiment illustrated in FIGS. 62-70 includes similarcomponents to the embodiment illustrated in FIGS. 1-9. For the sake ofbrevity, these similar components and the similar steps of using syringepackaging system 10E will not all be discussed in conjunction with theembodiment illustrated in FIGS. 62-70. In one embodiment, syringepackaging system 10E is compatible with the syringe assembly 13 and theoxygen absorber 18 shown in FIGS. 15-23.

Referring to FIGS. 62-70, a syringe packaging system 10E includes apackaging member 12E formed of a generally oxygen impermeable material.In one embodiment, a sealing member 15 (FIG. 2B) may be removablyattached to packaging member 12E. Packaging member 12E is sized andadapted to receive each of syringe barrel 14, plunger rod 16, and oxygenabsorber 18.

Referring to FIGS. 62-70, packaging member 12E includes a firstcompartment 100E, a second compartment 102E, a third compartment 104E, afirst or top end 110E, a second or bottom end, and a sidewall 114Eextending between top end 110E and bottom end. Packaging member 12Eincludes a locking lip 116E at top end 110E. Disposed below locking lip116E is an upper tray portion 118E having a cross-section that has agreater area than a cross-section disposed below upper tray portion118E, i.e., a compartment portion 120E, such that a shoulder 122E isdefined therebetween. Upper tray portion 118E receives and supportsflange 40 of syringe barrel 14 and flange 74 of plunger rod 16.

The compartment portion 120E includes a syringe barrel container 200 anda plunger rod and oxygen absorber container 202. The plunger rod andoxygen absorber container 202 forms second compartment 102E and thirdcompartment 104E which are sized and adapted to receive the plunger rod16 and the oxygen absorber 18 respectively therein. The syringe barrelcontainer 200 forms first compartment 100E which is sized and adapted toreceive the syringe barrel 14 therein. In one embodiment, the firstcompartment 100E, the second compartment 102E, and the third compartment104E of packaging member 12E are formed as a unitary packaging membercomponent or compartment. The syringe barrel container 200 and theplunger rod and oxygen absorber container 202 define a gas slot 206which maintains first compartment 100E, second compartment 102E, andthird compartment 104E in gaseous communication theretogether. Theinterior surface of plunger rod and oxygen absorber container 202includes ribs 204 extending along a longitudinal axis of plunger rod andoxygen absorber container 202 of packaging member 12E.

All of the components of syringe packaging system 10E may be constructedof any known material, and are desirably constructed of medical-gradepolymers.

Referring to FIGS. 62-70, packaging of syringe barrel 14, plunger rod16, and oxygen absorber 18 within packaging member 12E will now bedescribed. Initially, syringe barrel 14, plunger rod 16, and packagingmember 12E are sterilized according to techniques known to those ofordinary skill in the art as described above. In some embodiments,syringe barrel 14 may be pre-filled as described above.

Next, oxygen absorber 18 is received within third compartment 104E ofpackaging member 12E, i.e., plunger rod and oxygen absorber container202, such that oxygen absorber 18 is positioned vertically withinplunger rod and oxygen absorber container 202 as shown in FIG. 70. Tosecure oxygen absorber 18 within third compartment 104E of packagingmember 12E, oxygen absorber 18 is inserted or moved axially into plungerrod and oxygen absorber container 202 of packaging member 12E in adirection generally along arrow A (FIG. 1). As additional force isexerted on oxygen absorber 18 to axially move oxygen absorber 18 in thedirection generally along arrow A within plunger rod and oxygen absorbercontainer 202 of packaging member 12E, oxygen absorber 18 deforms ribs204 outward until oxygen absorber 18 advances to the bottom portion ofplunger rod and oxygen absorber container 202 of packaging member 12E.In this position, ribs 204 may abut, contact, or engage oxygen absorber18 and lock or secure oxygen absorber 18 within plunger rod and oxygenabsorber container 202 of third compartment 104E of packaging member 12Eby an interference fit between ribs 204 and oxygen absorber 18. Thisconfiguration ensures that packaging member 12E provides a thirdcompartment 104E that secures oxygen absorber 18 within packaging member12E such that oxygen absorber 18 is prevented from being removed frompackaging member 12E. This configuration also ensures that the oxygenabsorber 18 is maintained within the third compartment 104E and is notable to slide towards the first compartment 100E. Next, syringe barrel14 is inserted into syringe barrel container 200 of packaging member 12Eas shown in FIG. 70. Next, plunger rod 16 is inserted into plunger rodand oxygen absorber container 202 of packaging member 12E as shown inFIG. 70.

In this manner, with the packaging member 12E enclosing the syringebarrel 14, the plunger rod 16, and the oxygen absorber 18, the oxygenabsorber 18 is adapted to draw oxygen from the syringe barrel 14 and toabsorb oxygen contained within the first compartment 100E, the secondcompartment 102E, and the third compartment 104E of the packaging member12E.

Exemplary embodiments have been described above, however, those skilledin the art will appreciate that changes and modifications may be made tothese embodiments without departing from the scope and spirit of theinvention, which is defined by the claims.

What is claimed is:
 1. A syringe packaging system, comprising: a syringebarrel; a plunger rod; an oxygen absorber; a packaging member defining afirst compartment, a second compartment, and a third compartment, thefirst compartment, the second compartment, and the third compartmentseparate from each other and in gaseous communication, the firstcompartment structured to receive the syringe barrel therein, the secondcompartment structured to receive the plunger rod therein, and the thirdcompartment structured to receive the oxygen absorber therein; and apartition member associated with the packaging member, the partitionmember and the packaging member defining the first compartment, thesecond compartment, and the third compartment, wherein with thepackaging member enclosing the syringe barrel, the plunger rod, and theoxygen absorber, the oxygen absorber draws oxygen from within thesyringe barrel and absorbs oxygen contained within at least one of thefirst compartment, the second compartment, and the third compartment ofthe packaging member.
 2. The syringe packaging system of claim 1,wherein the syringe barrel includes a first end, a second end, and asidewall extending therebetween and defining a chamber having aninterior, the syringe barrel further comprising a stopper slidablydisposed within the interior of the chamber.
 3. The syringe packagingsystem of claim 2, wherein the plunger rod is engageable with a portionof the stopper.
 4. The syringe packaging system of claim 2, furthercomprising a fluid disposed within the chamber of the syringe barrel. 5.The syringe packaging system of claim 4, wherein with the packagingmember enclosing the syringe barrel, the plunger rod, and the oxygenabsorber, the oxygen absorber is adapted to draw oxygen from the fluiddisposed within the chamber of the syringe barrel.
 6. The syringepackaging system of claim 5, wherein the oxygen absorber is adapted todraw oxygen from the fluid disposed within the chamber through thestopper.
 7. The syringe packaging system of claim 5, wherein the oxygenabsorber is adapted to draw oxygen from the fluid disposed within thechamber through the syringe barrel.
 8. The syringe packaging system ofclaim 1, wherein the packaging member comprises a sealing member,wherein the packaging member and the sealing member enclose the syringebarrel, the plunger rod, and the oxygen absorber.
 9. The syringepackaging system of claim 1, wherein the first compartment, the secondcompartment, and the third compartment are formed as portions of aunitary compartment.
 10. The syringe packaging system of claim 1,wherein the partition member defines a plurality of gas holes allowingfor gaseous communication between at least two of the first compartment,the second compartment, and the third compartment.
 11. The syringepackaging system of claim 1, wherein the packaging member includes asidewall defining opposing slots for receiving the partition member. 12.The syringe packaging system of claim 1, wherein the packaging memberincludes a support member for engaging the plunger rod to secure theplunger rod within the packaging member.
 13. The syringe packagingsystem of claim 1, wherein the packaging member includes a supportmember for engaging the syringe barrel to secure the syringe barrelwithin the packaging member.
 14. The syringe packaging system of claim1, wherein the oxygen absorber includes a polyolefin based material. 15.A syringe packaging system, comprising: a syringe barrel having a firstend, a second end, and a sidewall extending therebetween and defining achamber having an interior; a stopper slidably disposed within theinterior of the chamber of the syringe barrel; a fluid disposed withinthe chamber of the syringe barrel, wherein at least one of the syringebarrel and the stopper are formed of an oxygen permeable material; aplunger rod engageable with a portion of the stopper; an oxygenabsorber; a packaging member formed of a generally oxygen impermeablematerial and defining a first compartment, a second compartment, and athird compartment, the first compartment, the second compartment, andthe third compartment separate from each other and in gaseouscommunication, the first compartment structured to receive the syringebarrel therein, the second compartment structured to receive the plungerrod therein, and the third compartment structured to receive the oxygenabsorber therein; and a partition member associated with the packagingmember, the partition member and the packaging member defining the firstcompartment, the second compartment, and the third compartment, whereinwith the packaging member enclosing the syringe barrel, the plunger rod,and the oxygen absorber, the oxygen absorber draws oxygen from the fluiddisposed within the chamber of the syringe barrel and absorbs oxygencontained within the packaging member.
 16. The syringe packaging systemof claim 15, wherein the oxygen absorber is adapted to draw oxygen fromthe fluid disposed within the chamber through the stopper.
 17. Thesyringe packaging system of claim 15, wherein the oxygen absorber isadapted to draw oxygen from the fluid disposed within the chamberthrough the syringe barrel.
 18. The syringe packaging system of claim15, wherein the packaging member comprises a sealing member, wherein thepackaging member and the sealing member enclose the syringe barrel, theplunger rod, and the oxygen absorber.
 19. The syringe packaging systemof claim 15, wherein the first compartment, the second compartment, andthe third compartment are formed as portions of a unitary compartment.20. The syringe packaging system of claim 15, wherein the packagingmember is formed of a polyester material or a polyamide material.
 21. Asyringe packaging system, comprising: a syringe barrel; an oxygenabsorber; a packaging member defining a first compartment and a separatesecond compartment, the first compartment and the second compartment ingaseous communication, the first compartment structured to receive thesyringe barrel therein and the second compartment structured to receivethe oxygen absorber therein; and a partition member associated with thepackaging member, the partition member and the packaging member definingthe first compartment and the second compartment, wherein with thepackaging member enclosing the syringe barrel and the oxygen absorber,the oxygen absorber draws oxygen from within the syringe barrel, andwherein the packaging member includes a sidewall defining opposing slotsthe opposing slots for receiving the partition member therein.
 22. Thesyringe packaging system of claim 21, wherein the syringe barrelincludes a first end, a second end, and a sidewall extendingtherebetween and defining a chamber having an interior, the syringebarrel further comprising a stopper slidably disposed within theinterior of the chamber.
 23. The syringe packaging system of claim 22,further comprising a fluid disposed within the chamber of the syringebarrel.
 24. The syringe packaging system of claim 23, wherein with thepackaging member enclosing the syringe barrel and the oxygen absorber,the oxygen absorber is adapted to draw oxygen from the fluid disposedwithin the chamber of the syringe barrel.
 25. The syringe packagingsystem of claim 24, wherein the oxygen absorber is adapted to drawoxygen from the fluid disposed within the chamber through the stopper.26. The syringe packaging system of claim 24, wherein the oxygenabsorber is adapted to draw oxygen from the fluid disposed within thechamber through the syringe barrel.
 27. A syringe packaging system,comprising: a syringe barrel; a plunger rod; an oxygen absorber; apackaging member defining a first compartment, a second compartment, anda third compartment, the first compartment, the second compartment, andthe third compartment in gaseous communication, the first compartmentstructured to receive the syringe barrel therein, the second compartmentstructured to receive the plunger rod therein, and the third compartmentstructured to receive the oxygen absorber therein; and a partitionmember receivable within the packaging member, the partition member andthe packaging member defining the first compartment, the secondcompartment, and the third compartment, wherein with the packagingmember enclosing the syringe barrel, the plunger rod, and the oxygenabsorber, the oxygen absorber draws oxygen from within the syringebarrel and absorbs oxygen contained within at least one of the firstcompartment, the second compartment, and the third compartment of thepackaging member.